P38 MAPK in the senescence of human and murine fibroblasts

Florence Debacq-Chainiaux, Emmanuelle Boilan, Jérémie Dedessus Le Moutier, Geoffroy Weemaels, Olivier Toussaint

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Résumé

Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38MAPK pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-related pathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.

langue originaleAnglais
titreAdvances in Experimental Medicine and Biology
Pages126-137
Nombre de pages12
Volume694
Les DOIs
Etat de la publicationPublié - 1 déc. 2010

Série de publications

NomAdvances in Experimental Medicine and Biology
Volume694
ISSN (imprimé)00652598

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