P38
                    MAPK in the senescence of human and murine fibroblasts

Florence Debacq-Chainiaux; Emmanuelle Boilan; Jérémie Dedessus Le Moutier; Geoffroy Weemaels; Olivier Toussaint

doi:10.1007/978-1-4419-7002-2_10

P38 ^MAPK in the senescence of human and murine fibroblasts

Florence Debacq-Chainiaux, Emmanuelle Boilan, Jérémie Dedessus Le Moutier, Geoffroy Weemaels, Olivier Toussaint

Résultats de recherche: Contribution dans un livre/un catalogue/un rapport/dans les actes d'une conférence › Chapitre (revu par des pairs) › Revue par des pairs

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Résumé

Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38MAPK pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-related pathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.

langue originale	Anglais
titre	Advances in Experimental Medicine and Biology
Pages	126-137
Nombre de pages	12
Volume	694
Les DOIs	https://doi.org/10.1007/978-1-4419-7002-2_10
Etat de la publication	Publié - 1 déc. 2010

Série de publications

Nom	Advances in Experimental Medicine and Biology
Volume	694
ISSN (imprimé)	00652598

SDG des Nations Unies

Ce résultat contribue à ou aux Objectifs de développement durable suivants

Accès au document

10.1007/978-1-4419-7002-2_10

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2010-24.Debacq_Ch_p38MAPK_Livre
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Contient cette citation

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abstract = "Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38MAPK pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-related pathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.",

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P38 ^MAPK in the senescence of human and murine fibroblasts. / Debacq-Chainiaux, Florence; Boilan, Emmanuelle; Le Moutier, Jérémie Dedessus et al.
Advances in Experimental Medicine and Biology. Vol 694 2010. p. 126-137 (Advances in Experimental Medicine and Biology; Vol 694).

Résultats de recherche: Contribution dans un livre/un catalogue/un rapport/dans les actes d'une conférence › Chapitre (revu par des pairs) › Revue par des pairs

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AU - Weemaels, Geoffroy

AU - Toussaint, Olivier

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P38 MAPK in the senescence of human and murine fibroblasts