Novel pharmaceutical compositions through co-crystallization of racetams and Li salts

J. Wouters; F. Grepioni; D. Braga; R.M. Kaminski; S. Rome; L. Aerts; L. Quéré

doi:10.1039/c3ce41539b

Novel pharmaceutical compositions through co-crystallization of racetams and Li salts

J. Wouters, F. Grepioni, D. Braga, R.M. Kaminski, S. Rome, L. Aerts, L. Quéré

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.

langue originale	Anglais
Pages (de - à)	8898-8902
Nombre de pages	5
journal	CrystEngComm
Volume	15
Numéro de publication	44
Les DOIs	https://doi.org/10.1039/c3ce41539b
Etat de la publication	Publié - 28 nov. 2013

Accès au document

10.1039/c3ce41539b

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Physico-chimie et caractérisation (PC2)
Johan Wouters (!!Manager) & Carmela Aprile (!!Manager)
Plateforme technologique Caracterisation physico-chimiques
Equipement/installations: Plateforme technolgique

CCDC 941339: Experimental Crystal Structure Determination
Aerts, L. (Contributeur), Braga, D. (Contributeur), Grepioni, F. (Contributeur), Kaminski, R. M. (Contributeur), Quéré, L. (Contributeur), Rome, S. (Contributeur) & Wouters, J. (Contributeur), Cambridge Crystallographic Data Centre, 1 janv. 2013
DOI: 10.5517/cc10ljsx, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc10ljsx&sid=DataCite
Ensemble de données
CCDC 941338: Experimental Crystal Structure Determination
Aerts, L. (Contributeur), Braga, D. (Contributeur), Grepioni, F. (Contributeur), Kaminski, R. M. (Contributeur), Quéré, L. (Contributeur), Rome, S. (Contributeur) & Wouters, J. (Contributeur), Cambridge Crystallographic Data Centre, 1 janv. 2013
DOI: 10.5517/cc10ljrw, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc10ljrw&sid=DataCite
Ensemble de données
CCDC 941337: Experimental Crystal Structure Determination
Aerts, L. (Contributeur), Braga, D. (Contributeur), Grepioni, F. (Contributeur), Kaminski, R. M. (Contributeur), Quéré, L. (Contributeur), Rome, S. (Contributeur) & Wouters, J. (Contributeur), Cambridge Crystallographic Data Centre, 1 janv. 2013
DOI: 10.5517/cc10ljqv, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc10ljqv&sid=DataCite
Ensemble de données

Contient cette citation

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abstract = "Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.",

author = "J. Wouters and F. Grepioni and D. Braga and R.M. Kaminski and S. Rome and L. Aerts and L. Qu{\'e}r{\'e}",

year = "2013",

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doi = "10.1039/c3ce41539b",

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AU - Wouters, J.

AU - Grepioni, F.

AU - Braga, D.

AU - Kaminski, R.M.

AU - Rome, S.

AU - Aerts, L.

AU - Quéré, L.

PY - 2013/11/28

Y1 - 2013/11/28

N2 - Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.

AB - Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.

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DO - 10.1039/c3ce41539b

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JO - CrystEngComm

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IS - 44

ER -

Novel pharmaceutical compositions through co-crystallization of racetams and Li salts

Résumé

Accès au document

Autres fichiers et liens

Empreinte digitale

Équipement

Physico-chimie et caractérisation (PC2)

Ensembles de données

CCDC 941339: Experimental Crystal Structure Determination

CCDC 941338: Experimental Crystal Structure Determination

CCDC 941337: Experimental Crystal Structure Determination

Contient cette citation