Novel pharmaceutical compositions through co-crystallization of racetams and Li salts

J. Wouters, F. Grepioni, D. Braga, R.M. Kaminski, S. Rome, L. Aerts, L. Quéré

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.
langue originaleAnglais
Pages (de - à)8898-8902
Nombre de pages5
journalCrystEngComm
Volume15
Numéro de publication44
Les DOIs
Etat de la publicationPublié - 28 nov. 2013

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