NF-κB in photodynamic therapy: Discrepancies of a master regulator

Jean Yves Matroule, Cedric Volanti, Jacques Piette

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Tumor eradication by photodynamic therapy (PDT) results from the onset of distinct killing processes. In addition to the well-known necrotic and apoptotic mechanisms, PDT initiates an inflammatory response that will indirectly contribute to tumor clearance. The NF-κB transcription factor is a major regulator of inflammation modulating the expression of cytokines, chemokines, and adhesion molecules in various cell types in response to a large number of stimuli. Besides, NF-κB regulates the expression of antiapoptotic genes, cyclooxygenases (COXs) and metalloproteinases (MMPs) as well, thereby favoring tumor cell proliferation and dissemination. In the present review, we aim to summarize the current knowledge on NF-κB status following photosensitization of cancer cells and endothelial cells. In order to unravel the NF-κB impact in PDT tumorigenicity and recurrences, we will stress the discrepancies of this major transcription factor relative to the signaling cascades underlying its activation and the cellular effects triggered by its translocation into the nucleus and its binding to its target genes.
langue originaleAnglais
Pages (de - à)1241-1246
Nombre de pages6
journalPhotochemistry and Photobiology
Volume82
Numéro de publication5
Les DOIs
Etat de la publicationPublié - 1 sept. 2006
Modification externeOui

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