TY - JOUR
T1 - Neuroimaging insights into the pathophysiology of sleep disorders
AU - Desseilles, Martin
AU - Dang-Vu, Thanh
AU - Schabus, Manuel
AU - Sterpenich, Virginie
AU - Maquet, Pierre
AU - Schwartz, Sophie
PY - 2008/6
Y1 - 2008/6
N2 - Neuroimaging methods can be used to investigate whether sleep disorders are associated with specific changes in brain structure or regional activity. However, it is still unclear how these new data might improve our understanding of the pathophysiology underlying adult sleep disorders. Here we review functional brain imaging findings in major intrinsic sleep disorders (i.e., idiopathic insomnia, narcolepsy, and obstructive sleep apnea) and in abnormal motor behavior during sleep (i.e., periodic limb movement disorder and REM sleep behavior disorder). The studies reviewed include neuroanatomical assessments (voxel-based morphometry, magnetic resonance spectroscopy), metabolic/functional investigations (positron emission tomography, single photon emission computed tomography, functional magnetic resonance imaging), and ligand marker measurements. Based on the current state of the research, we suggest that brain imaging is a useful approach to assess the structural and functional correlates of sleep impairments as well as better understand the cerebral consequences of various therapeutic approaches. Modem neuroimaging techniques therefore provide a valuable tool to gain insight into possible pathophysiological mechanisms of sleep disorders in adult humans.
AB - Neuroimaging methods can be used to investigate whether sleep disorders are associated with specific changes in brain structure or regional activity. However, it is still unclear how these new data might improve our understanding of the pathophysiology underlying adult sleep disorders. Here we review functional brain imaging findings in major intrinsic sleep disorders (i.e., idiopathic insomnia, narcolepsy, and obstructive sleep apnea) and in abnormal motor behavior during sleep (i.e., periodic limb movement disorder and REM sleep behavior disorder). The studies reviewed include neuroanatomical assessments (voxel-based morphometry, magnetic resonance spectroscopy), metabolic/functional investigations (positron emission tomography, single photon emission computed tomography, functional magnetic resonance imaging), and ligand marker measurements. Based on the current state of the research, we suggest that brain imaging is a useful approach to assess the structural and functional correlates of sleep impairments as well as better understand the cerebral consequences of various therapeutic approaches. Modem neuroimaging techniques therefore provide a valuable tool to gain insight into possible pathophysiological mechanisms of sleep disorders in adult humans.
KW - Brain
KW - Comorbidity
KW - Depression
KW - Dopamine
KW - Electroencephalography
KW - Humans
KW - Iron
KW - Magnetic Resonance Imaging
KW - Narcolepsy
KW - Positron-Emission Tomography
KW - REM Sleep Behavior Disorder
KW - Receptors, Opioid
KW - Restless Legs Syndrome
KW - Sleep Apnea, Obstructive
KW - Sleep Disorders
KW - Sleep Initiation and Maintenance Disorders
KW - Tomography, Emission-Computed, Single-Photon
M3 - Article
C2 - 18548822
SN - 0161-8105
VL - 31
SP - 777
EP - 794
JO - Sleep
JF - Sleep
IS - 6
ER -