TY - JOUR
T1 - Neural correlates of performance variability during motor sequence acquisition
AU - Albouy, Geneviève
AU - Sterpenich, Virginie
AU - Vandewalle, Gilles
AU - Darsaud, Annabelle
AU - Gais, Steffen
AU - Rauchs, Géraldine
AU - Desseilles, Martin
AU - Boly, Mélanie
AU - Dang-Vu, Thanh
AU - Balteau, Evelyne
AU - Degueldre, Christian
AU - Phillips, Christophe
AU - Luxen, André
AU - Maquet, Pierre
N1 - Copyright © 2012 Elsevier Inc. All rights reserved.
PY - 2012/3
Y1 - 2012/3
N2 - During the initial training of a motor sequence, performance becomes progressively faster but also increasingly reproducible and consistent. However, performance temporarily becomes more variable at mid-training, reflecting a change in the motor representation and the eventual selection of the optimal performance mode (Adi-Japha et al., 2008). At the cerebral level, whereas performance speed is known to be related to the activity in cerebello-cortical and striato-cortical networks, the neural correlates of performance variability remain unknown. We characterized the latter using functional magnetic resonance imaging (fMRI) during the initial training to the Finger Tapping Task (FTT), during which participants produced a 5-element finger sequence on a keyboard with their left non-dominant hand. Our results show that responses in the precuneus decrease whereas responses in the caudate nucleus increase as performance becomes more consistent. In addition, a variable performance is associated with enhanced interaction between the hippocampus and fronto-parietal areas and between the striatum and frontal areas. Our results suggest that these dynamic large-scale interactions represent a cornerstone in the implementation of consistent motor behavior in humans.
AB - During the initial training of a motor sequence, performance becomes progressively faster but also increasingly reproducible and consistent. However, performance temporarily becomes more variable at mid-training, reflecting a change in the motor representation and the eventual selection of the optimal performance mode (Adi-Japha et al., 2008). At the cerebral level, whereas performance speed is known to be related to the activity in cerebello-cortical and striato-cortical networks, the neural correlates of performance variability remain unknown. We characterized the latter using functional magnetic resonance imaging (fMRI) during the initial training to the Finger Tapping Task (FTT), during which participants produced a 5-element finger sequence on a keyboard with their left non-dominant hand. Our results show that responses in the precuneus decrease whereas responses in the caudate nucleus increase as performance becomes more consistent. In addition, a variable performance is associated with enhanced interaction between the hippocampus and fronto-parietal areas and between the striatum and frontal areas. Our results suggest that these dynamic large-scale interactions represent a cornerstone in the implementation of consistent motor behavior in humans.
KW - Brain
KW - Female
KW - Humans
KW - Learning
KW - Magnetic Resonance Imaging
KW - Male
KW - Task Performance and Analysis
KW - Young Adult
U2 - 10.1016/j.neuroimage.2011.12.049
DO - 10.1016/j.neuroimage.2011.12.049
M3 - Article
C2 - 22227134
SN - 1053-8119
VL - 60
SP - 324
EP - 331
JO - NeuroImage
JF - NeuroImage
IS - 1
ER -