Projets par an
Résumé
NETosis is a form of neutrophil death leading to the release of extracellular chromatin and the assembling of proteins, including antiviral proteins, primed by an initial pathogenic stimulus. Under certain specific conditions, neutrophils can exhibit a double-edged activity. This event has been implicated in COVID-19 among other conditions. Neutrophil extracellular traps (NETs) are involved in the pathogenesis of COVID-19 by promoting a pro-inflammatory and a procoagulant state leading to multiorgan failure. This particular form of host defense promoted by neutrophils is closely related to the well-known cytokine storm observed in severe COVID-19 patients. These two elements therefore represent possible targets for treatment of severe SARS-CoV-2 infections.
| langue originale | Anglais |
|---|---|
| Numéro d'article | 708302 |
| Pages (de - à) | 708302 |
| journal | Frontiers in Pharmacology |
| Volume | 12 |
| Les DOIs | |
| Etat de la publication | Publié - 5 août 2021 |
SDG des Nations Unies
Ce résultat contribue à ou aux Objectifs de développement durable suivants
Accès au document
Autres fichiers et liens
Empreinte digitale
Examiner les sujets de recherche de « NETosis and the Immune System in COVID-19: Mechanisms and Potential Treatments ». Ensemble, ils forment une empreinte digitale unique.Projets
- 1 Actif
-
The COVILAB project : Clinical laboratory investigations related to COVID-19
Douxfils, J. (Promoteur), Dogne, J.-M. (Co-Promoteur), FAVRESSE, J. (Co-investigateur), Tre-Hardy, M. (Co-investigateur), Mullier, F. (Co-investigateur), Haguet, H. (Chercheur), Hardy, M. (Chercheur), Melchionda, S. (Chercheur), BOUVY, C. (Chercheur), Morimont, L. (Chercheur), Gillot, C. (Chercheur), Djokoto, H. (Chercheur), Alpan, L. (Technicien), Devel, P. (Technicien), Modaffari, E. (Technicien) & Maloteau, V. (Technicien)
13/03/20 → …
Projet: Recherche