NETosis and the Immune System in COVID-19: Mechanisms and Potential Treatments

Constant Gillot; Julien Favresse; François Mullier; Thomas Lecompte; Jean-Michel Dogné; Jonathan Douxfils

doi:10.3389/fphar.2021.708302

NETosis and the Immune System in COVID-19: Mechanisms and Potential Treatments

Constant Gillot, Julien Favresse, François Mullier, Thomas Lecompte, Jean-Michel Dogné, Jonathan Douxfils

Résultats de recherche: Contribution à un journal/une revue › Article de revue › Revue par des pairs

Résumé

NETosis is a form of neutrophil death leading to the release of extracellular chromatin and the assembling of proteins, including antiviral proteins, primed by an initial pathogenic stimulus. Under certain specific conditions, neutrophils can exhibit a double-edged activity. This event has been implicated in COVID-19 among other conditions. Neutrophil extracellular traps (NETs) are involved in the pathogenesis of COVID-19 by promoting a pro-inflammatory and a procoagulant state leading to multiorgan failure. This particular form of host defense promoted by neutrophils is closely related to the well-known cytokine storm observed in severe COVID-19 patients. These two elements therefore represent possible targets for treatment of severe SARS-CoV-2 infections.

langue originale	Anglais
Numéro d'article	708302
Pages (de - à)	708302
journal	Frontiers in Pharmacology
Volume	12
Les DOIs	https://doi.org/10.3389/fphar.2021.708302
Etat de la publication	Publié - 5 août 2021

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10.3389/fphar.2021.708302

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The COVILAB project : Clinical laboratory investigations related to COVID-19
Douxfils, J., Dogne, J., FAVRESSE, J., Tre-Hardy, M., Mullier, F., Haguet, H., Hardy, M., Melchionda, S., BOUVY, C., Morimont, L., Gillot, C., Djokoto, H., Alpan, L., Devel, P., Modaffari, E. & Maloteau, V.
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title = "NETosis and the Immune System in COVID-19: Mechanisms and Potential Treatments",

abstract = "NETosis is a form of neutrophil death leading to the release of extracellular chromatin and the assembling of proteins, including antiviral proteins, primed by an initial pathogenic stimulus. Under certain specific conditions, neutrophils can exhibit a double-edged activity. This event has been implicated in COVID-19 among other conditions. Neutrophil extracellular traps (NETs) are involved in the pathogenesis of COVID-19 by promoting a pro-inflammatory and a procoagulant state leading to multiorgan failure. This particular form of host defense promoted by neutrophils is closely related to the well-known cytokine storm observed in severe COVID-19 patients. These two elements therefore represent possible targets for treatment of severe SARS-CoV-2 infections.",

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note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Gillot, Favresse, Mullier, Lecompte, Dogn{\'e} and Douxfils.",

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month = aug,

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doi = "10.3389/fphar.2021.708302",

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T2 - Mechanisms and Potential Treatments

AU - Gillot, Constant

AU - Favresse, Julien

AU - Mullier, François

AU - Lecompte, Thomas

AU - Dogné, Jean-Michel

AU - Douxfils, Jonathan

PY - 2021/8/5

Y1 - 2021/8/5

N2 - NETosis is a form of neutrophil death leading to the release of extracellular chromatin and the assembling of proteins, including antiviral proteins, primed by an initial pathogenic stimulus. Under certain specific conditions, neutrophils can exhibit a double-edged activity. This event has been implicated in COVID-19 among other conditions. Neutrophil extracellular traps (NETs) are involved in the pathogenesis of COVID-19 by promoting a pro-inflammatory and a procoagulant state leading to multiorgan failure. This particular form of host defense promoted by neutrophils is closely related to the well-known cytokine storm observed in severe COVID-19 patients. These two elements therefore represent possible targets for treatment of severe SARS-CoV-2 infections.

AB - NETosis is a form of neutrophil death leading to the release of extracellular chromatin and the assembling of proteins, including antiviral proteins, primed by an initial pathogenic stimulus. Under certain specific conditions, neutrophils can exhibit a double-edged activity. This event has been implicated in COVID-19 among other conditions. Neutrophil extracellular traps (NETs) are involved in the pathogenesis of COVID-19 by promoting a pro-inflammatory and a procoagulant state leading to multiorgan failure. This particular form of host defense promoted by neutrophils is closely related to the well-known cytokine storm observed in severe COVID-19 patients. These two elements therefore represent possible targets for treatment of severe SARS-CoV-2 infections.

KW - COVID-19

KW - inflammation

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DO - 10.3389/fphar.2021.708302

M3 - Review article

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SN - 1663-9812

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SP - 708302

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

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ER -

NETosis and the Immune System in COVID-19: Mechanisms and Potential Treatments

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The COVILAB project : Clinical laboratory investigations related to COVID-19

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