Neisseria cinerea expresses a functional factor H binding protein which is recognised by immune responses elicited by meningococcal vaccines.

Hayley Lavender, Katy Poncin, Christoph M. Tang

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. Capsular polysaccharide vaccines are available against meningococcal serogroups A, C, W and Y. More recently two protein based vaccines, Bexsero® and Trumenba®, have been licenced against meningococcal serogroup B strains; both vaccines contain meningococcal factor H binding protein (fHbp). fHbp is a surface exposed lipoprotein which binds the negative complement regulator, complement factor H (CFH), thereby inhibiting the alternative pathway of complement activation. Recent analysis of available genomes has indicated that some commensal Neisseria species also contain genes that potentially encode fHbp, although the function of these genes and how immunisation with fHbp-containing vaccines could affect the commensal flora have yet to be established. Here we show that the commensal species Neisseria cinerea expresses functional fHbp on its surface and is responsible for recruitment of CFH by the bacterium. N. cinerea fHbp binds CFH at similar affinity as meningococcal fHbp, and promotes survival of N. cinerea in human serum. We examined the potential impact of fHbp-containing vaccines on N. cinerea We found that immunisation with Bexsero® elicits serum bactericidal activity against N. cinerea, which is primarily directed against fHbp. The shared function of fHbp in N. cinerea and N. meningitidis, and cross reactive responses elicited by Bexsero® suggest that the introduction of fHbp-containing vaccines has the potential to affect carriage of N. cinerea and other commensal species.

langueAnglais
Numéro d'articlee00305-17
journalInfection and Immunity
Volume85
Numéro10
Date de mise en ligne précoce2017
Les DOIs
étatPublié - 2017

Empreinte digitale

Neisseria cinerea
Meningococcal Vaccines
Complement Factor H
Carrier Proteins
Vaccines
Neisseria meningitidis
Immunization
Alternative Complement Pathway
Neisseria

mots-clés

    Citer ceci

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    title = "Neisseria cinerea expresses a functional factor H binding protein which is recognised by immune responses elicited by meningococcal vaccines.",
    abstract = "Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. Capsular polysaccharide vaccines are available against meningococcal serogroups A, C, W and Y. More recently two protein based vaccines, Bexsero{\circledR} and Trumenba{\circledR}, have been licenced against meningococcal serogroup B strains; both vaccines contain meningococcal factor H binding protein (fHbp). fHbp is a surface exposed lipoprotein which binds the negative complement regulator, complement factor H (CFH), thereby inhibiting the alternative pathway of complement activation. Recent analysis of available genomes has indicated that some commensal Neisseria species also contain genes that potentially encode fHbp, although the function of these genes and how immunisation with fHbp-containing vaccines could affect the commensal flora have yet to be established. Here we show that the commensal species Neisseria cinerea expresses functional fHbp on its surface and is responsible for recruitment of CFH by the bacterium. N. cinerea fHbp binds CFH at similar affinity as meningococcal fHbp, and promotes survival of N. cinerea in human serum. We examined the potential impact of fHbp-containing vaccines on N. cinerea We found that immunisation with Bexsero{\circledR} elicits serum bactericidal activity against N. cinerea, which is primarily directed against fHbp. The shared function of fHbp in N. cinerea and N. meningitidis, and cross reactive responses elicited by Bexsero{\circledR} suggest that the introduction of fHbp-containing vaccines has the potential to affect carriage of N. cinerea and other commensal species.",
    keywords = "Complement, fHbp, Neisseria cinerea, Neisseria meningitidis, Vaccine",
    author = "Hayley Lavender and Katy Poncin and Tang, {Christoph M.}",
    note = "Copyright {\circledC} 2017 Lavender et al.",
    year = "2017",
    doi = "10.1128/IAI.00305-17",
    language = "English",
    volume = "85",
    journal = "Infection and Immunity",
    issn = "0019-9567",
    publisher = "American Society for Microbiology",
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    Neisseria cinerea expresses a functional factor H binding protein which is recognised by immune responses elicited by meningococcal vaccines. / Lavender, Hayley; Poncin, Katy; Tang, Christoph M.

    Dans: Infection and Immunity, Vol 85, Numéro 10, e00305-17, 2017.

    Résultats de recherche: Contribution à un journal/une revueArticle

    TY - JOUR

    T1 - Neisseria cinerea expresses a functional factor H binding protein which is recognised by immune responses elicited by meningococcal vaccines.

    AU - Lavender, Hayley

    AU - Poncin, Katy

    AU - Tang, Christoph M.

    N1 - Copyright © 2017 Lavender et al.

    PY - 2017

    Y1 - 2017

    N2 - Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. Capsular polysaccharide vaccines are available against meningococcal serogroups A, C, W and Y. More recently two protein based vaccines, Bexsero® and Trumenba®, have been licenced against meningococcal serogroup B strains; both vaccines contain meningococcal factor H binding protein (fHbp). fHbp is a surface exposed lipoprotein which binds the negative complement regulator, complement factor H (CFH), thereby inhibiting the alternative pathway of complement activation. Recent analysis of available genomes has indicated that some commensal Neisseria species also contain genes that potentially encode fHbp, although the function of these genes and how immunisation with fHbp-containing vaccines could affect the commensal flora have yet to be established. Here we show that the commensal species Neisseria cinerea expresses functional fHbp on its surface and is responsible for recruitment of CFH by the bacterium. N. cinerea fHbp binds CFH at similar affinity as meningococcal fHbp, and promotes survival of N. cinerea in human serum. We examined the potential impact of fHbp-containing vaccines on N. cinerea We found that immunisation with Bexsero® elicits serum bactericidal activity against N. cinerea, which is primarily directed against fHbp. The shared function of fHbp in N. cinerea and N. meningitidis, and cross reactive responses elicited by Bexsero® suggest that the introduction of fHbp-containing vaccines has the potential to affect carriage of N. cinerea and other commensal species.

    AB - Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. Capsular polysaccharide vaccines are available against meningococcal serogroups A, C, W and Y. More recently two protein based vaccines, Bexsero® and Trumenba®, have been licenced against meningococcal serogroup B strains; both vaccines contain meningococcal factor H binding protein (fHbp). fHbp is a surface exposed lipoprotein which binds the negative complement regulator, complement factor H (CFH), thereby inhibiting the alternative pathway of complement activation. Recent analysis of available genomes has indicated that some commensal Neisseria species also contain genes that potentially encode fHbp, although the function of these genes and how immunisation with fHbp-containing vaccines could affect the commensal flora have yet to be established. Here we show that the commensal species Neisseria cinerea expresses functional fHbp on its surface and is responsible for recruitment of CFH by the bacterium. N. cinerea fHbp binds CFH at similar affinity as meningococcal fHbp, and promotes survival of N. cinerea in human serum. We examined the potential impact of fHbp-containing vaccines on N. cinerea We found that immunisation with Bexsero® elicits serum bactericidal activity against N. cinerea, which is primarily directed against fHbp. The shared function of fHbp in N. cinerea and N. meningitidis, and cross reactive responses elicited by Bexsero® suggest that the introduction of fHbp-containing vaccines has the potential to affect carriage of N. cinerea and other commensal species.

    KW - Complement

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    KW - Neisseria cinerea

    KW - Neisseria meningitidis

    KW - Vaccine

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    U2 - 10.1128/IAI.00305-17

    DO - 10.1128/IAI.00305-17

    M3 - Article

    VL - 85

    JO - Infection and Immunity

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    JF - Infection and Immunity

    SN - 0019-9567

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