Multivalent glycoconjugates as anti-pathogenic agents

Anna Bernardi, Jesus Jiménez-Barbero, Alessandro Casnati, Cristina De Castro, Tamis Darbre, Franck Fieschi, Jukka Finne, Horst Funken, Karl Erich Jaeger, Martina Lahmann, Thisbe K. Lindhorst, Marco Marradi, Paul Messner, Antonio Molinaro, Paul V. Murphy, Cristina Nativi, Stefan Oscarson, Soledad Penadés, Francesco Peri, Roland J. PietersOlivier Renaudet, Jean Louis Reymond, Barbara Richichi, Javier Rojo, Francesco Sansone, Christina Schäffer, W. Bruce Turnbull, Trinidad Velasco-Torrijos, Sébastien Vidal, Stéphane Vincent, Tom Wennekes, Han Zuilhof, Anne Imberty

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Résumé

Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.

langue originaleAnglais
Pages (de - à)4709-4727
Nombre de pages19
journalChemical Society Reviews
Volume42
Numéro de publication11
Les DOIs
Etat de la publicationPublié - 7 juin 2013

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