Multivalent glycoconjugates as anti-pathogenic agents

Anna Bernardi, Jesus Jiménez-Barbero, Alessandro Casnati, Cristina De Castro, Tamis Darbre, Franck Fieschi, Jukka Finne, Horst Funken, Karl Erich Jaeger, Martina Lahmann, Thisbe K. Lindhorst, Marco Marradi, Paul Messner, Antonio Molinaro, Paul V. Murphy, Cristina Nativi, Stefan Oscarson, Soledad Penadés, Francesco Peri, Roland J. PietersOlivier Renaudet, Jean Louis Reymond, Barbara Richichi, Javier Rojo, Francesco Sansone, Christina Schäffer, W. Bruce Turnbull, Trinidad Velasco-Torrijos, Sébastien Vidal, Stéphane Vincent, Tom Wennekes, Han Zuilhof, Anne Imberty

Résultats de recherche: Contribution à un journal/une revueArticle

106 Downloads (Pure)

Résumé

Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.

langue originaleAnglais
Pages (de - à)4709-4727
Nombre de pages19
journalChemical Society Reviews
Volume42
Numéro de publication11
Les DOIs
étatPublié - 7 juin 2013

Empreinte digitale

Glycoconjugates
Bacteria
Carbohydrates
Immune system
Pathogens
Scaffolds
Microorganisms
Polysaccharides
Lipopolysaccharides
Adhesion
Vaccines
Topology
Anti-Bacterial Agents
Ligands
Proteins

Citer ceci

Bernardi, A., Jiménez-Barbero, J., Casnati, A., De Castro, C., Darbre, T., Fieschi, F., ... Imberty, A. (2013). Multivalent glycoconjugates as anti-pathogenic agents. Chemical Society Reviews, 42(11), 4709-4727. https://doi.org/10.1039/c2cs35408j
Bernardi, Anna ; Jiménez-Barbero, Jesus ; Casnati, Alessandro ; De Castro, Cristina ; Darbre, Tamis ; Fieschi, Franck ; Finne, Jukka ; Funken, Horst ; Jaeger, Karl Erich ; Lahmann, Martina ; Lindhorst, Thisbe K. ; Marradi, Marco ; Messner, Paul ; Molinaro, Antonio ; Murphy, Paul V. ; Nativi, Cristina ; Oscarson, Stefan ; Penadés, Soledad ; Peri, Francesco ; Pieters, Roland J. ; Renaudet, Olivier ; Reymond, Jean Louis ; Richichi, Barbara ; Rojo, Javier ; Sansone, Francesco ; Schäffer, Christina ; Turnbull, W. Bruce ; Velasco-Torrijos, Trinidad ; Vidal, Sébastien ; Vincent, Stéphane ; Wennekes, Tom ; Zuilhof, Han ; Imberty, Anne. / Multivalent glycoconjugates as anti-pathogenic agents. Dans: Chemical Society Reviews. 2013 ; Vol 42, Numéro 11. p. 4709-4727.
@article{eae612df6fcd4287b8f1c6e3fb79306a,
title = "Multivalent glycoconjugates as anti-pathogenic agents",
abstract = "Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.",
author = "Anna Bernardi and Jesus Jim{\'e}nez-Barbero and Alessandro Casnati and {De Castro}, Cristina and Tamis Darbre and Franck Fieschi and Jukka Finne and Horst Funken and Jaeger, {Karl Erich} and Martina Lahmann and Lindhorst, {Thisbe K.} and Marco Marradi and Paul Messner and Antonio Molinaro and Murphy, {Paul V.} and Cristina Nativi and Stefan Oscarson and Soledad Penad{\'e}s and Francesco Peri and Pieters, {Roland J.} and Olivier Renaudet and Reymond, {Jean Louis} and Barbara Richichi and Javier Rojo and Francesco Sansone and Christina Sch{\"a}ffer and Turnbull, {W. Bruce} and Trinidad Velasco-Torrijos and S{\'e}bastien Vidal and St{\'e}phane Vincent and Tom Wennekes and Han Zuilhof and Anne Imberty",
year = "2013",
month = "6",
day = "7",
doi = "10.1039/c2cs35408j",
language = "English",
volume = "42",
pages = "4709--4727",
journal = "Chemical Society Reviews",
issn = "0306-0012",
publisher = "Royal Society of Chemistry",
number = "11",

}

Bernardi, A, Jiménez-Barbero, J, Casnati, A, De Castro, C, Darbre, T, Fieschi, F, Finne, J, Funken, H, Jaeger, KE, Lahmann, M, Lindhorst, TK, Marradi, M, Messner, P, Molinaro, A, Murphy, PV, Nativi, C, Oscarson, S, Penadés, S, Peri, F, Pieters, RJ, Renaudet, O, Reymond, JL, Richichi, B, Rojo, J, Sansone, F, Schäffer, C, Turnbull, WB, Velasco-Torrijos, T, Vidal, S, Vincent, S, Wennekes, T, Zuilhof, H & Imberty, A 2013, 'Multivalent glycoconjugates as anti-pathogenic agents', Chemical Society Reviews, VOL. 42, Numéro 11, p. 4709-4727. https://doi.org/10.1039/c2cs35408j

Multivalent glycoconjugates as anti-pathogenic agents. / Bernardi, Anna; Jiménez-Barbero, Jesus; Casnati, Alessandro; De Castro, Cristina; Darbre, Tamis; Fieschi, Franck; Finne, Jukka; Funken, Horst; Jaeger, Karl Erich; Lahmann, Martina; Lindhorst, Thisbe K.; Marradi, Marco; Messner, Paul; Molinaro, Antonio; Murphy, Paul V.; Nativi, Cristina; Oscarson, Stefan; Penadés, Soledad; Peri, Francesco; Pieters, Roland J.; Renaudet, Olivier; Reymond, Jean Louis; Richichi, Barbara; Rojo, Javier; Sansone, Francesco; Schäffer, Christina; Turnbull, W. Bruce; Velasco-Torrijos, Trinidad; Vidal, Sébastien; Vincent, Stéphane; Wennekes, Tom; Zuilhof, Han; Imberty, Anne.

Dans: Chemical Society Reviews, Vol 42, Numéro 11, 07.06.2013, p. 4709-4727.

Résultats de recherche: Contribution à un journal/une revueArticle

TY - JOUR

T1 - Multivalent glycoconjugates as anti-pathogenic agents

AU - Bernardi, Anna

AU - Jiménez-Barbero, Jesus

AU - Casnati, Alessandro

AU - De Castro, Cristina

AU - Darbre, Tamis

AU - Fieschi, Franck

AU - Finne, Jukka

AU - Funken, Horst

AU - Jaeger, Karl Erich

AU - Lahmann, Martina

AU - Lindhorst, Thisbe K.

AU - Marradi, Marco

AU - Messner, Paul

AU - Molinaro, Antonio

AU - Murphy, Paul V.

AU - Nativi, Cristina

AU - Oscarson, Stefan

AU - Penadés, Soledad

AU - Peri, Francesco

AU - Pieters, Roland J.

AU - Renaudet, Olivier

AU - Reymond, Jean Louis

AU - Richichi, Barbara

AU - Rojo, Javier

AU - Sansone, Francesco

AU - Schäffer, Christina

AU - Turnbull, W. Bruce

AU - Velasco-Torrijos, Trinidad

AU - Vidal, Sébastien

AU - Vincent, Stéphane

AU - Wennekes, Tom

AU - Zuilhof, Han

AU - Imberty, Anne

PY - 2013/6/7

Y1 - 2013/6/7

N2 - Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.

AB - Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.

UR - http://www.scopus.com/inward/record.url?scp=84876740610&partnerID=8YFLogxK

U2 - 10.1039/c2cs35408j

DO - 10.1039/c2cs35408j

M3 - Article

C2 - 23254759

AN - SCOPUS:84876740610

VL - 42

SP - 4709

EP - 4727

JO - Chemical Society Reviews

JF - Chemical Society Reviews

SN - 0306-0012

IS - 11

ER -

Bernardi A, Jiménez-Barbero J, Casnati A, De Castro C, Darbre T, Fieschi F et al. Multivalent glycoconjugates as anti-pathogenic agents. Chemical Society Reviews. 2013 juin 7;42(11):4709-4727. https://doi.org/10.1039/c2cs35408j