Molecular lipophilicity potential by clip, a reliable tool for the description of the 3d distribution of lipophilicity: Application to 3- phenyloxazolidin-2-one, a prototype series of reversible MAO(A) inhibitors

F. Ooms, J. Wouters, Sonia Collin, F. Durant, S. Jegham, P. George

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

The capacity factor of eleven derivatives belonging to a prototype series of 3-phenyloxazolidin-2-one, reversible MAO inhibitors, was measured and compared to the calculated log P(calc) using the CLIP package. We demonstrate that this Molecular Lipophilicity Potential (MLP) approach is a valuable tool to estimate log P(calc) of such compounds.

langue originaleAnglais
Pages (de - à)1425-1430
Nombre de pages6
journalBioorganic & Medicinal Chemistry Letters
Volume8
Numéro de publication11
Les DOIs
Etat de la publicationPublié - 2 juin 1998

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