TY - JOUR
T1 - Modulation of the arachidonic cascade with ω3 fatty acids or analogues
T2 - Potential therapeutic benefits
AU - Roland, Isabelle
AU - de Leval, Xavier
AU - Evrard, Brigitte
AU - Pirotte, Bernard
AU - Dogné, Jean Michel
AU - Delattre, Luc
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Increasing interest in the role of ω3 fatty acids has arisen in these latest years since evidence of their implication in the cardioprotective fish based diet of the Inuit has been demonstrated. Furthermore, several in vitro, in vivo and epidemiological studies support the benefit of this fatty acids intake in various pathological states such as in the cardiovascular, cancer, inflammation, psychiatric, paediatric, pulmonary, dermatological and ophthalmologic fields. This review will focus on metabolism and pharmacological implication of ω3 fatty acids intake as well as its interest in the prevention or treatment of the above-mentioned pathologies.
AB - Increasing interest in the role of ω3 fatty acids has arisen in these latest years since evidence of their implication in the cardioprotective fish based diet of the Inuit has been demonstrated. Furthermore, several in vitro, in vivo and epidemiological studies support the benefit of this fatty acids intake in various pathological states such as in the cardiovascular, cancer, inflammation, psychiatric, paediatric, pulmonary, dermatological and ophthalmologic fields. This review will focus on metabolism and pharmacological implication of ω3 fatty acids intake as well as its interest in the prevention or treatment of the above-mentioned pathologies.
KW - Cancer
KW - Cardiovascular disease
KW - Inflammation
KW - Psychiatric disorders
KW - ω3 fatty acid
KW - ω6/ω3 ratio
UR - http://www.scopus.com/inward/record.url?scp=3242677874&partnerID=8YFLogxK
U2 - 10.2174/1389557043403738
DO - 10.2174/1389557043403738
M3 - Short survey
C2 - 15279600
AN - SCOPUS:3242677874
SN - 1389-5575
VL - 4
SP - 659
EP - 668
JO - Mini-reviews in medicinal chemistry
JF - Mini-reviews in medicinal chemistry
IS - 6
ER -
