Modeling impact and cost-effectiveness of driving-Y gene drives for malaria elimination in the Democratic Republic of the Congo

Nawaphan Metchanun, Christian Borgemeister, Gaston Amzati, Joachim von Braun, Milen Nikolov, Prashanth Selvaraj, Jaline Gerardin

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Malaria elimination will be challenging in countries that currently continue to bear high malaria burden. Sex-ratio-distorting gene drives, such as driving-Y, could play a role in an integrated elimination strategy if they can effectively suppress vector populations. Using a spatially explicit, agent-based model of malaria transmission in eight provinces spanning the range of transmission intensities across the Democratic Republic of the Congo, we predict the impact and cost-effectiveness of integrating driving-Y gene drive mosquitoes in malaria elimination strategies that include existing interventions such as insecticide-treated nets and case management of symptomatic malaria. Gene drive mosquitoes could eliminate malaria and were the most cost-effective intervention overall if the drive component was highly effective with at least 95% X-shredder efficiency at relatively low fertility cost, and associated cost of deployment below 7.17 $int per person per year. Suppression gene drive could be a cost-effective supplemental intervention for malaria elimination, but tight constraints on drive effectiveness and cost ceilings may limit its feasibility.

langue originaleAnglais
Pages (de - à)132-148
Nombre de pages17
journalEvolutionary Applications
Volume15
Numéro de publication1
Les DOIs
Etat de la publicationPublié - janv. 2022
Modification externeOui

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