MicroRNA Expression Profile in Human Macrophages in Response to Leishmania major Infection

Julien Lemaire, Ghada Mkannez, Fatma Z Guerfali, Cindy Gustin, Hanène Attia, Rabiaa M Sghaier, Koussay Dellagi, Dhafer Laouini, Patricia Renard, Sysco Consortium

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

48 Téléchargements (Pure)


Leishmania (L.) are intracellular protozoan parasites able to survive and replicate in the hostile phagolysosomal environment of infected macrophages. They cause leishmaniasis, a heterogeneous group of worldwide-distributed affections, representing a paradigm of neglected diseases that are mainly embedded in impoverished populations. To establish successful infection and ensure their own survival, Leishmania have developed sophisticated strategies to subvert the host macrophage responses. Despite a wealth of gained crucial information, these strategies still remain poorly understood. MicroRNAs (miRNAs), an evolutionarily conserved class of endogenous 22-nucleotide non-coding RNAs, are described to participate in the regulation of almost every cellular process investigated so far. They regulate the expression of target genes both at the levels of mRNA stability and translation; changes in their expression have a profound effect on their target transcripts.
langue originaleAnglais
Pages (de - à)e2478
journalPLoS neglected tropical diseases
Numéro de publication10
Les DOIs
Etat de la publicationPublié - 2013

Empreinte digitale

Examiner les sujets de recherche de « MicroRNA Expression Profile in Human Macrophages in Response to Leishmania major Infection ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation