Macroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteins

Stéphane Demine, Sébastien Michel, Kayleen Vannuvel, Anaïs Wanet, Patricia Renard, Thierry Arnould

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Résumé

Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.

langue originaleAnglais
Pages (de - à)168-203
Nombre de pages36
journalCells
Volume1
Numéro de publication2
Les DOIs
Etat de la publicationPublié - 2012

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  • Thèses de l'étudiant

    Effects of a mitochondrial uncoupling on lipolysis and adipokine expression in 3T3-L1 murine adipocytes

    Author: Demine, S., 26 avr. 2016

    Superviseur: Arnould, T. (Promoteur), Jadot, M. (Copromoteur), De Bolle, X. (Président), Raes, M. (Jury), KEIJER, J. (Personne externe) (Jury) & Bertrand, L. (Personne externe) (Jury)

    Thèse de l'étudiant: Doc typesDocteur en Sciences

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