Linking ABC transporters to the hallmarks of cancer

Résultats de recherche: Contribution à un journal/une revueArticle de revueRevue par des pairs

Résumé

Human ATP-binding cassette (ABC) transporters are ubiquitously expressed and transport a broad range of endogenous and xenobiotic substrates across extra- and intracellular membranes. Mutations in ABC genes cause 21 monogenic diseases, and polymorphisms in these genes are associated with susceptibility to complex diseases. ABC transporters also play a major role in drug bioavailability, and they mediate multidrug resistance in cancer. At least 13 ABC transporters were shown to be involved in drug resistance in vitro. In the past decade, efforts have been made to elucidate their roles in tumor biology. Herein, we explore their involvement in tumorigenesis, focusing on the hallmarks of cells as they make their way from normalcy to neoplastic growth states.

langue originaleAnglais
Pages (de - à)124-134
Nombre de pages11
journalTrends in Cancer
Volume10
Numéro de publication2
Les DOIs
Etat de la publicationPublié - 24 oct. 2023

Empreinte digitale

Examiner les sujets de recherche de « Linking ABC transporters to the hallmarks of cancer ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation