Résumé
The α-proteobacteria are a fascinating group of free-living, symbiotic and pathogenic organisms, including the Brucella genus, which is responsible for a worldwide zoonosis. One common feature of α-proteobacteria is the presence of a conserved response regulator called CtrA, first described in the model bacterium Caulobacter crescentus, where it controls gene expression at different stages of the cell cycle. Here, we focus on Brucella abortus and other intracellular α-proteobacteria in order to better assess the potential role of CtrA in the infectious context. Comparative genomic analyses of the CtrA control pathway revealed the conservation of specific modules, as well as the acquisition of new factors during evolution. The comparison of CtrA regulons also suggests that specific clades of α-proteobacteria acquired distinct functions under its control, depending on the essentiality of the transcription factor. Other CtrA-controlled functions, for instance motility and DNA repair, are proposed to be more ancestral. Altogether, these analyses provide an interesting example of the plasticity of a regulation network, subject to the constraints of inherent imperatives such as cell division and the adaptations to diversified environmental niches.
langue originale | Anglais |
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Pages (de - à) | 500-513 |
Nombre de pages | 14 |
journal | FEMS microbiology reviews |
Volume | 42 |
Numéro de publication | 4 |
Date de mise en ligne précoce | 2018 |
Les DOIs | |
Etat de la publication | Publié - 1 juil. 2018 |
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Laboratoire de sécurité biologique au niveau 3 (BL3)
Xavier De Bolle (!!Manager)
Plateforme technologique Laboratoire de securite biologique au niveau 3Equipement/installations: Plateforme technolgique
Thèses de l'étudiant
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Study of cell cycle regulators and DNA repair following alkylating stress in Brucella abortus
Auteur: Poncin, K., 11 déc. 2018Superviseur: De Bolle, X. (Promoteur), Hallez, R. (Président), VIOLLIER, P. (Personne externe) (Jury), Matić, I. (Personne externe) (Jury) & Hallet, B. (Personne externe) (Jury)
Student thesis: Doc types › Docteur en Sciences
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