Large-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs

Bernard Lambermont, Pierre Delanaye, Jean-Michel Dogné, Alexandre Ghuysen, Nathalie Janssen, Bernard Dubois, Thomas Desaive, Philippe Kolh, Vincent D'Orio, Jean-Marie Krzesinski

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Hemodynamic improvement in patients suffering from both septic shock and renal failure who received hemofiltration suggested that an extrarenal epuration technique could be of interest in patients with septic shock alone. However, most of the studies using continuous venovenous hemofiltration (CVVH) in this setting evidenced neither cytokine clearance nor significant reduction in their plasma level. Lack of significant clearance was explained in part by the small size of the membrane pores. Therefore, we investigated the effects of large-pore membrane hemofiltration (LPHF) during endotoxic shock in pigs on interleukin 6 (IL-6) and interleukin 10 (IL-10) clearances, and on right ventricular (RV)-vascular coupling. Thirteen anesthetized healthy pigs weighing 20-30 kg were divided into two groups. In the Endo group (n = 6), the pigs received a 0.5-mg/kg endotoxin infusion over a period of 30 mins from T0 to T30. In the EndoHF group (n = 7), LPHF (cutoff = 80 kDa) and an ultrafiltration rate of 45 mL/kg/h were started 30 mins after the end of the endotoxin infusion, from T60 to T240. In this model of porcine endotoxic shock, LPHF was responsible for a significant clearance of IL-6 (20 mL/min) and Il-10 (14 mL/min), and for an improvement in RV-vascular coupling.
langue originaleAnglais
Pages (de - à)560-4
Nombre de pages5
journalArtificial organs
Volume30
Numéro de publication7
Les DOIs
étatPublié - juil. 2006

Empreinte digitale

Hemofiltration
Septic Shock
Blood Vessels
Swine
Cytokines
Membranes
Endotoxins
Interleukin-6
Hemodynamics
Weighing
Ultrafiltration
Interleukin-10
Renal Insufficiency
Plasmas

Citer ceci

Lambermont, Bernard ; Delanaye, Pierre ; Dogné, Jean-Michel ; Ghuysen, Alexandre ; Janssen, Nathalie ; Dubois, Bernard ; Desaive, Thomas ; Kolh, Philippe ; D'Orio, Vincent ; Krzesinski, Jean-Marie. / Large-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs. Dans: Artificial organs. 2006 ; Vol 30, Numéro 7. p. 560-4.
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abstract = "Hemodynamic improvement in patients suffering from both septic shock and renal failure who received hemofiltration suggested that an extrarenal epuration technique could be of interest in patients with septic shock alone. However, most of the studies using continuous venovenous hemofiltration (CVVH) in this setting evidenced neither cytokine clearance nor significant reduction in their plasma level. Lack of significant clearance was explained in part by the small size of the membrane pores. Therefore, we investigated the effects of large-pore membrane hemofiltration (LPHF) during endotoxic shock in pigs on interleukin 6 (IL-6) and interleukin 10 (IL-10) clearances, and on right ventricular (RV)-vascular coupling. Thirteen anesthetized healthy pigs weighing 20-30 kg were divided into two groups. In the Endo group (n = 6), the pigs received a 0.5-mg/kg endotoxin infusion over a period of 30 mins from T0 to T30. In the EndoHF group (n = 7), LPHF (cutoff = 80 kDa) and an ultrafiltration rate of 45 mL/kg/h were started 30 mins after the end of the endotoxin infusion, from T60 to T240. In this model of porcine endotoxic shock, LPHF was responsible for a significant clearance of IL-6 (20 mL/min) and Il-10 (14 mL/min), and for an improvement in RV-vascular coupling.",
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author = "Bernard Lambermont and Pierre Delanaye and Jean-Michel Dogn{\'e} and Alexandre Ghuysen and Nathalie Janssen and Bernard Dubois and Thomas Desaive and Philippe Kolh and Vincent D'Orio and Jean-Marie Krzesinski",
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Lambermont, B, Delanaye, P, Dogné, J-M, Ghuysen, A, Janssen, N, Dubois, B, Desaive, T, Kolh, P, D'Orio, V & Krzesinski, J-M 2006, 'Large-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs', Artificial organs, VOL. 30, Numéro 7, p. 560-4. https://doi.org/10.1111/j.1525-1594.2006.00260.x

Large-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs. / Lambermont, Bernard; Delanaye, Pierre; Dogné, Jean-Michel; Ghuysen, Alexandre; Janssen, Nathalie; Dubois, Bernard; Desaive, Thomas; Kolh, Philippe; D'Orio, Vincent; Krzesinski, Jean-Marie.

Dans: Artificial organs, Vol 30, Numéro 7, 07.2006, p. 560-4.

Résultats de recherche: Contribution à un journal/une revueArticle

TY - JOUR

T1 - Large-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs

AU - Lambermont, Bernard

AU - Delanaye, Pierre

AU - Dogné, Jean-Michel

AU - Ghuysen, Alexandre

AU - Janssen, Nathalie

AU - Dubois, Bernard

AU - Desaive, Thomas

AU - Kolh, Philippe

AU - D'Orio, Vincent

AU - Krzesinski, Jean-Marie

PY - 2006/7

Y1 - 2006/7

N2 - Hemodynamic improvement in patients suffering from both septic shock and renal failure who received hemofiltration suggested that an extrarenal epuration technique could be of interest in patients with septic shock alone. However, most of the studies using continuous venovenous hemofiltration (CVVH) in this setting evidenced neither cytokine clearance nor significant reduction in their plasma level. Lack of significant clearance was explained in part by the small size of the membrane pores. Therefore, we investigated the effects of large-pore membrane hemofiltration (LPHF) during endotoxic shock in pigs on interleukin 6 (IL-6) and interleukin 10 (IL-10) clearances, and on right ventricular (RV)-vascular coupling. Thirteen anesthetized healthy pigs weighing 20-30 kg were divided into two groups. In the Endo group (n = 6), the pigs received a 0.5-mg/kg endotoxin infusion over a period of 30 mins from T0 to T30. In the EndoHF group (n = 7), LPHF (cutoff = 80 kDa) and an ultrafiltration rate of 45 mL/kg/h were started 30 mins after the end of the endotoxin infusion, from T60 to T240. In this model of porcine endotoxic shock, LPHF was responsible for a significant clearance of IL-6 (20 mL/min) and Il-10 (14 mL/min), and for an improvement in RV-vascular coupling.

AB - Hemodynamic improvement in patients suffering from both septic shock and renal failure who received hemofiltration suggested that an extrarenal epuration technique could be of interest in patients with septic shock alone. However, most of the studies using continuous venovenous hemofiltration (CVVH) in this setting evidenced neither cytokine clearance nor significant reduction in their plasma level. Lack of significant clearance was explained in part by the small size of the membrane pores. Therefore, we investigated the effects of large-pore membrane hemofiltration (LPHF) during endotoxic shock in pigs on interleukin 6 (IL-6) and interleukin 10 (IL-10) clearances, and on right ventricular (RV)-vascular coupling. Thirteen anesthetized healthy pigs weighing 20-30 kg were divided into two groups. In the Endo group (n = 6), the pigs received a 0.5-mg/kg endotoxin infusion over a period of 30 mins from T0 to T30. In the EndoHF group (n = 7), LPHF (cutoff = 80 kDa) and an ultrafiltration rate of 45 mL/kg/h were started 30 mins after the end of the endotoxin infusion, from T60 to T240. In this model of porcine endotoxic shock, LPHF was responsible for a significant clearance of IL-6 (20 mL/min) and Il-10 (14 mL/min), and for an improvement in RV-vascular coupling.

KW - Animals

KW - Coronary Vessels

KW - Cytokines

KW - Hemofiltration

KW - Shock, Septic

KW - Swine

KW - Ventricular Function

U2 - 10.1111/j.1525-1594.2006.00260.x

DO - 10.1111/j.1525-1594.2006.00260.x

M3 - Article

C2 - 16836739

VL - 30

SP - 560

EP - 564

JO - Artificial organs

JF - Artificial organs

SN - 0160-564X

IS - 7

ER -