Ionic co-crystals of racetams: Solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg2+ and Ca2+ chlorides

Fabrizia Grepioni; Johan Wouters; Dario Braga; Saverio Nanna; Baptiste Fours; Gérard Coquerel; Geraldine Longfils; Sandrine Rome; Luc Aerts; Luc Quéré

doi:10.1039/c4ce00409d

Ionic co-crystals of racetams: Solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg²⁺ and Ca²⁺ chlorides

Fabrizia Grepioni, Johan Wouters, Dario Braga, Saverio Nanna, Baptiste Fours, Gérard Coquerel, Geraldine Longfils, Sandrine Rome, Luc Aerts, Luc Quéré

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

Mechanochemical and solution based reactions of solid brivaracetam (BRV) and seletracetam (SEL), antiepileptic drugs from UCB's pipeline, with the inorganic salts MgCl₂ and CaCl₂, yield ionic co-crystals with changed or improved physico-chemical properties with respect to pure drugs (melting point, hygroscopicity, crystal morphology). All co-crystals are characterized via a combination of solid-state techniques, i.e. single crystal and powder X-ray diffraction, variable temperature X-ray diffraction, DSC, TGA and hot-stage microscopy (HSM).

langue originale	Anglais
Pages (de - à)	5887-5896
Nombre de pages	10
journal	CrystEngComm
Volume	16
Numéro de publication	26
Les DOIs	https://doi.org/10.1039/c4ce00409d
Etat de la publication	Publié - 14 juil. 2014
Modification externe	Oui

Accès au document

10.1039/c4ce00409d

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Link to publication in Scopus

Physico-chimie et caractérisation (PC2)
Johan Wouters (!!Manager) & Carmela Aprile (!!Manager)
Plateforme technologique Caracterisation physico-chimiques
Equipement/installations: Plateforme technolgique

CCDC 988343: Experimental Crystal Structure Determination
Grepioni, F. (Créateur), Wouters, J. (Contributeur), Braga, D. (Créateur), Nanna, S. (Créateur), Fours, B. (Créateur), Coquerel, G. (Créateur), Longfils, G. (Contributeur), Rome, S. (Créateur), Aerts, L. (Créateur) & Quéré, L. (Créateur), University of Namur, 14 juil. 2014
DOI: 10.5517/cc125g1r, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc125g1r&sid=DataCite
Ensemble de données
CCDC 988340: Experimental Crystal Structure Determination
Grepioni, F. (Créateur), Wouters, J. (Contributeur), Braga, D. (Créateur), Nanna, S. (Créateur), Fours, B. (Créateur), Coquerel, G. (Créateur), Longfils, G. (Contributeur), Rome, S. (Créateur), Aerts, L. (Créateur) & Quéré, L. (Créateur), University of Namur, 14 juil. 2014
DOI: 10.5517/cc125fym, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc125fym&sid=DataCite
Ensemble de données
CCDC 988342: Experimental Crystal Structure Determination
Grepioni, F. (Créateur), Wouters, J. (Contributeur), Braga, D. (Créateur), Nanna, S. (Créateur), Fours, B. (Créateur), Coquerel, G. (Créateur), Longfils, G. (Contributeur), Rome, S. (Créateur), Aerts, L. (Créateur) & Quéré, L. (Créateur), University of Namur, 14 juil. 2014
DOI: 10.5517/cc125g0q, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc125g0q&sid=DataCite
Ensemble de données

Contient cette citation

@article{f817e9d799bc469c9fcd1c9447668379,

title = "Ionic co-crystals of racetams: Solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg2+ and Ca2+ chlorides",

abstract = "Mechanochemical and solution based reactions of solid brivaracetam (BRV) and seletracetam (SEL), antiepileptic drugs from UCB's pipeline, with the inorganic salts MgCl2 and CaCl2, yield ionic co-crystals with changed or improved physico-chemical properties with respect to pure drugs (melting point, hygroscopicity, crystal morphology). All co-crystals are characterized via a combination of solid-state techniques, i.e. single crystal and powder X-ray diffraction, variable temperature X-ray diffraction, DSC, TGA and hot-stage microscopy (HSM).",

author = "Fabrizia Grepioni and Johan Wouters and Dario Braga and Saverio Nanna and Baptiste Fours and G{\'e}rard Coquerel and Geraldine Longfils and Sandrine Rome and Luc Aerts and Luc Qu{\'e}r{\'e}",

year = "2014",

month = jul,

day = "14",

doi = "10.1039/c4ce00409d",

language = "English",

volume = "16",

pages = "5887--5896",

journal = "CrystEngComm",

issn = "1466-8033",

publisher = "Royal Society of Chemistry",

number = "26",

}

Ionic co-crystals of racetams: Solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg²⁺ and Ca²⁺ chlorides. / Grepioni, Fabrizia; Wouters, Johan; Braga, Dario et al.
Dans: CrystEngComm, Vol 16, Numéro 26, 14.07.2014, p. 5887-5896.

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

TY - JOUR

T1 - Ionic co-crystals of racetams

T2 - Solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg2+ and Ca2+ chlorides

AU - Grepioni, Fabrizia

AU - Wouters, Johan

AU - Braga, Dario

AU - Nanna, Saverio

AU - Fours, Baptiste

AU - Coquerel, Gérard

AU - Longfils, Geraldine

AU - Rome, Sandrine

AU - Aerts, Luc

AU - Quéré, Luc

PY - 2014/7/14

Y1 - 2014/7/14

N2 - Mechanochemical and solution based reactions of solid brivaracetam (BRV) and seletracetam (SEL), antiepileptic drugs from UCB's pipeline, with the inorganic salts MgCl2 and CaCl2, yield ionic co-crystals with changed or improved physico-chemical properties with respect to pure drugs (melting point, hygroscopicity, crystal morphology). All co-crystals are characterized via a combination of solid-state techniques, i.e. single crystal and powder X-ray diffraction, variable temperature X-ray diffraction, DSC, TGA and hot-stage microscopy (HSM).

AB - Mechanochemical and solution based reactions of solid brivaracetam (BRV) and seletracetam (SEL), antiepileptic drugs from UCB's pipeline, with the inorganic salts MgCl2 and CaCl2, yield ionic co-crystals with changed or improved physico-chemical properties with respect to pure drugs (melting point, hygroscopicity, crystal morphology). All co-crystals are characterized via a combination of solid-state techniques, i.e. single crystal and powder X-ray diffraction, variable temperature X-ray diffraction, DSC, TGA and hot-stage microscopy (HSM).

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U2 - 10.1039/c4ce00409d

DO - 10.1039/c4ce00409d

M3 - Article

AN - SCOPUS:84902504240

SN - 1466-8033

VL - 16

SP - 5887

EP - 5896

JO - CrystEngComm

JF - CrystEngComm

IS - 26

ER -

Ionic co-crystals of racetams: Solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg2+ and Ca2+ chlorides

Résumé

Accès au document

Autres fichiers et liens

Empreinte digitale

Équipement

Physico-chimie et caractérisation (PC2)

Ensembles de données

CCDC 988343: Experimental Crystal Structure Determination

CCDC 988340: Experimental Crystal Structure Determination

CCDC 988342: Experimental Crystal Structure Determination

Contient cette citation

Ionic co-crystals of racetams: Solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg²⁺ and Ca²⁺ chlorides