Ionic co-crystals of racetams: Solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg2+ and Ca2+ chlorides

Fabrizia Grepioni, Johan Wouters, Dario Braga, Saverio Nanna, Baptiste Fours, Gérard Coquerel, Geraldine Longfils, Sandrine Rome, Luc Aerts, Luc Quéré

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Résumé

Mechanochemical and solution based reactions of solid brivaracetam (BRV) and seletracetam (SEL), antiepileptic drugs from UCB's pipeline, with the inorganic salts MgCl2 and CaCl2, yield ionic co-crystals with changed or improved physico-chemical properties with respect to pure drugs (melting point, hygroscopicity, crystal morphology). All co-crystals are characterized via a combination of solid-state techniques, i.e. single crystal and powder X-ray diffraction, variable temperature X-ray diffraction, DSC, TGA and hot-stage microscopy (HSM).

langue originaleAnglais
Pages (de - à)5887-5896
Nombre de pages10
journalCrystEngComm
Volume16
Numéro de publication26
Les DOIs
Etat de la publicationPublié - 14 juil. 2014
Modification externeOui

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