Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

Zhaokui Jin; Yanyuan Wen; Liwei Xiong; Tian Yang; Penghe Zhao; Liwei Tan; Tianfu Wang; Zhiyong Qian; Bao Lian Su; Qianjun He

doi:10.1039/c7cc01576c

Intratumoral H₂O₂-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

Zhaokui Jin, Yanyuan Wen, Liwei Xiong, Tian Yang, Penghe Zhao, Liwei Tan, Tianfu Wang, Zhiyong Qian, Bao Lian Su, Qianjun He

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

A new H₂O₂-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H₂O₂-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.

langue originale	Anglais
Pages (de - à)	5557-5560
Nombre de pages	4
journal	Chemical Communications
Volume	53
Numéro de publication	40
Les DOIs	https://doi.org/10.1039/c7cc01576c
Etat de la publication	Publié - 1 janv. 2017
Modification externe	Oui

Accès au document

10.1039/c7cc01576c

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Link to publication in Scopus

Contient cette citation

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title = "Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy",

abstract = "A new H2O2-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H2O2-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.",

author = "Zhaokui Jin and Yanyuan Wen and Liwei Xiong and Tian Yang and Penghe Zhao and Liwei Tan and Tianfu Wang and Zhiyong Qian and Su, {Bao Lian} and Qianjun He",

year = "2017",

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T1 - Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

AU - Jin, Zhaokui

AU - Wen, Yanyuan

AU - Xiong, Liwei

AU - Yang, Tian

AU - Zhao, Penghe

AU - Tan, Liwei

AU - Wang, Tianfu

AU - Qian, Zhiyong

AU - Su, Bao Lian

AU - He, Qianjun

PY - 2017/1/1

Y1 - 2017/1/1

N2 - A new H2O2-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H2O2-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.

AB - A new H2O2-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H2O2-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.

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U2 - 10.1039/c7cc01576c

DO - 10.1039/c7cc01576c

M3 - Article

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AN - SCOPUS:85021640269

SN - 1359-7345

VL - 53

SP - 5557

EP - 5560

JO - Chemical Communications

JF - Chemical Communications

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