TY - JOUR
T1 - Intratumoral high-payload delivery and acid-responsive release of H2 for efficient cancer therapy using the ammonia borane-loaded mesoporous silica nanomedicine
AU - Yang, Tian
AU - Jin, Zhaokui
AU - Wang, Zhihao
AU - Zhao, Penghe
AU - Zhao, Bin
AU - Fan, Mingjian
AU - Chen, Lihua
AU - Wang, Tianfu
AU - Su, Bao Lian
AU - He, Qianjun
N1 - Funding Information:
We greatly appreciate the help of Prof. Fei Yan, Dr. Zijun Wei and Caiyun Tang (SIAT, CAS) in hydrogen detection experiments, and Dr. Yaxin Hu, Zhaoke Pi, Dien Ye, Xifeng Lu and Han Xu (HSC, SZU) in cell and animal experiments, and Zhihao Wang and Zhu Kou (SKLATMSP, WUT) in material characterization. We thank the financial support from National Natural Science Foundation of China (Grant No. 81701827 ), Shenzhen Basic Research Program (No. JCYJ20170302151858466 ), Shenzhen Peacock Plan (No. KQTD2016053112051497 ), Natural Science Foundation of SZU (No. 827-000143 ), the Fundamental Research Funds for the Shenzhen University, China (No. 2016076 ), State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and Wuhan University of Technology (No. 2017-KF-6 ).
Publisher Copyright:
© 2018 Elsevier Ltd
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Hydrogen gas therapy as an emerging and promising therapy strategy has overwhelming advantages especially in bio-safety compared with other gas therapy routes, but is facing a great challenge in the long-term, highly-concentrated, deeply-seated disease site-specific administration of hydrogen gas, owing to its low solubility, high but aimless diffusibility in vivo. Herein, we propose to construct an ammonia borane-loaded mesoporous silica nanomedicine (AB@MSN) to realize the intratumoral high-payload delivery and in situ acid-controlled release of hydrogen gas. The constructed AB@MSN nanomedicine has a superhigh H2 loading capacity (130.6 mg/g, more than 1370 times higher than that of the traditional H2@liposome nanomedicine) and a highly acid-responsive sustained release behavior, exhibiting high anticancer efficacies and high bio-safety in vitro and in vivo. The proposed nanomedicine-based strategy opens a new window for precision high-efficacy hydrogen therapy.
AB - Hydrogen gas therapy as an emerging and promising therapy strategy has overwhelming advantages especially in bio-safety compared with other gas therapy routes, but is facing a great challenge in the long-term, highly-concentrated, deeply-seated disease site-specific administration of hydrogen gas, owing to its low solubility, high but aimless diffusibility in vivo. Herein, we propose to construct an ammonia borane-loaded mesoporous silica nanomedicine (AB@MSN) to realize the intratumoral high-payload delivery and in situ acid-controlled release of hydrogen gas. The constructed AB@MSN nanomedicine has a superhigh H2 loading capacity (130.6 mg/g, more than 1370 times higher than that of the traditional H2@liposome nanomedicine) and a highly acid-responsive sustained release behavior, exhibiting high anticancer efficacies and high bio-safety in vitro and in vivo. The proposed nanomedicine-based strategy opens a new window for precision high-efficacy hydrogen therapy.
KW - Anticancer
KW - Controlled release
KW - Drug delivery
KW - Hydrogen therapy
KW - Mesoporous silica nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85042314576&partnerID=8YFLogxK
U2 - 10.1016/j.apmt.2018.01.008
DO - 10.1016/j.apmt.2018.01.008
M3 - Article
AN - SCOPUS:85042314576
SN - 2352-9407
VL - 11
SP - 136
EP - 143
JO - Applied Materials Today
JF - Applied Materials Today
ER -