Activités par an
Mitochondria-to-nucleus communication, known as retrograde signaling, is important to adjust the nuclear gene expression in response to organelle dysfunction. Among the transcription factors described to respond to mitochondrial stress, CHOP-10 is activated by respiratory chain inhibition, mitochondrial accumulation of unfolded proteins and mtDNA mutations. In this study, we show that altered/impaired expression of mtDNA induces CHOP-10 expression in a signaling pathway that depends on the eIF2α/ATF4 axis of the integrated stress response rather than on the mitochondrial unfolded protein response.
Thierry Arnould (Poster)23 mai 2016 → 26 mai 2016
Activité: Types de Participation ou d'organisation d'un événement › Participation à un atelier/workshop, un séminaire, un cours
Study of the transcriptional responses to the inhibition of the expression of the mitochondrial genome: analysis of the activation of the mitochondrial unfolded protein response and the integrated stress responseAuthor: Michel, S., 24 oct. 2014
Thèse de l'étudiant: Doc types › Docteur en Sciences