Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response

Sebastien Michel; Morgane Canonne; Thierry Arnould; Patricia Renard

doi:10.1016/j.mito.2015.01.005

Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response

Sebastien Michel, Morgane Canonne, Thierry Arnould, Patricia Renard

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

250 Téléchargements (Pure)

Résumé

Mitochondria-to-nucleus communication, known as retrograde signaling, is important to adjust the nuclear gene expression in response to organelle dysfunction. Among the transcription factors described to respond to mitochondrial stress, CHOP-10 is activated by respiratory chain inhibition, mitochondrial accumulation of unfolded proteins and mtDNA mutations. In this study, we show that altered/impaired expression of mtDNA induces CHOP-10 expression in a signaling pathway that depends on the eIF2α/ATF4 axis of the integrated stress response rather than on the mitochondrial unfolded protein response.

langue originale	Anglais
Pages (de - à)	58-68
Nombre de pages	11
journal	Mitochondrion
Volume	21
Date de mise en ligne précoce	30 janv. 2015
Les DOIs	https://doi.org/10.1016/j.mito.2015.01.005
Etat de la publication	Publié - 1 mars 2015

Accès au document

10.1016/j.mito.2015.01.005

MITOCHONDRION2015Michel-S Version finale publiée, 1,97 MB

Autres fichiers et liens

Link to publication in Scopus

Empreinte digitale

Examiner les sujets de recherche de « Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response ». Ensemble, ils forment une empreinte digitale unique.

Embo Workshop : Molecular Biology of Mitochondrial Gene Expression
Arnould, T. (Poster)
23 mai 2016 → 26 mai 2016
Activité: Participation ou organisation d'un événement › Participation à un atelier/workshop, un séminaire, un cours

Study of the transcriptional responses to the inhibition of the expression of the mitochondrial genome: analysis of the activation of the mitochondrial unfolded protein response and the integrated stress response
Michel, S. (Auteur), Renard, P. (Promoteur), Arnould, T. (Copromoteur), De Bolle, X. (Président), Hamer, I. (Jury), FRANCAUX, M. (Jury) & WIESNER, R. (Jury), 24 oct. 2014
Student thesis: Doc types › Docteur en Sciences

Contient cette citation

@article{ba71c8bf8fe14317a517d55d1a2b11a5,

title = "Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response",

abstract = "Mitochondria-to-nucleus communication, known as retrograde signaling, is important to adjust the nuclear gene expression in response to organelle dysfunction. Among the transcription factors described to respond to mitochondrial stress, CHOP-10 is activated by respiratory chain inhibition, mitochondrial accumulation of unfolded proteins and mtDNA mutations. In this study, we show that altered/impaired expression of mtDNA induces CHOP-10 expression in a signaling pathway that depends on the eIF2α/ATF4 axis of the integrated stress response rather than on the mitochondrial unfolded protein response.",

keywords = "C/EBP homologous protein 10 (CHOP-10), Doxycycline, Integrated stress response (ISR), Mitochondria unfolded protein response (mtUPR), Mitochondrial dysfunction, MtDNA depletion",

author = "Sebastien Michel and Morgane Canonne and Thierry Arnould and Patricia Renard",

year = "2015",

month = mar,

day = "1",

doi = "10.1016/j.mito.2015.01.005",

language = "English",

volume = "21",

pages = "58--68",

journal = "Mitochondrion",

issn = "1567-7249",

publisher = "Elsevier",

}

Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response. / Michel, Sebastien; Canonne, Morgane ; Arnould, Thierry et al.
Dans: Mitochondrion, Vol 21, 01.03.2015, p. 58-68.

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

TY - JOUR

T1 - Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response

AU - Michel, Sebastien

AU - Canonne, Morgane

AU - Arnould, Thierry

AU - Renard, Patricia

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Mitochondria-to-nucleus communication, known as retrograde signaling, is important to adjust the nuclear gene expression in response to organelle dysfunction. Among the transcription factors described to respond to mitochondrial stress, CHOP-10 is activated by respiratory chain inhibition, mitochondrial accumulation of unfolded proteins and mtDNA mutations. In this study, we show that altered/impaired expression of mtDNA induces CHOP-10 expression in a signaling pathway that depends on the eIF2α/ATF4 axis of the integrated stress response rather than on the mitochondrial unfolded protein response.

AB - Mitochondria-to-nucleus communication, known as retrograde signaling, is important to adjust the nuclear gene expression in response to organelle dysfunction. Among the transcription factors described to respond to mitochondrial stress, CHOP-10 is activated by respiratory chain inhibition, mitochondrial accumulation of unfolded proteins and mtDNA mutations. In this study, we show that altered/impaired expression of mtDNA induces CHOP-10 expression in a signaling pathway that depends on the eIF2α/ATF4 axis of the integrated stress response rather than on the mitochondrial unfolded protein response.

KW - C/EBP homologous protein 10 (CHOP-10)

KW - Doxycycline

KW - Integrated stress response (ISR)

KW - Mitochondria unfolded protein response (mtUPR)

KW - Mitochondrial dysfunction

KW - MtDNA depletion

UR - http://www.scopus.com/inward/record.url?scp=84922635413&partnerID=8YFLogxK

U2 - 10.1016/j.mito.2015.01.005

DO - 10.1016/j.mito.2015.01.005

M3 - Article

AN - SCOPUS:84922635413

SN - 1567-7249

VL - 21

SP - 58

EP - 68

JO - Mitochondrion

JF - Mitochondrion

ER -

Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response

Résumé

Accès au document

Autres fichiers et liens

Empreinte digitale

Activités

Embo Workshop : Molecular Biology of Mitochondrial Gene Expression

Thèses de l'étudiant

Study of the transcriptional responses to the inhibition of the expression of the mitochondrial genome: analysis of the activation of the mitochondrial unfolded protein response and the integrated stress response

Contient cette citation