Inflammation response at the transcriptional level of HepG2 cells induced by multi-walled carbon nanotubes

J.-P. Piret, S. Vankoningsloo, Jorge Humberto Mejia Mendoza, F. Noël, S. Lucas, C. Saout, O. Toussaint

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Résumé

Poor information are currently available about the biological effects of multi-walled carbon nanotubes (MWCNT) on the liver. In this study, we evaluated the effects of MWCNT at the transcriptional level on the classical in vitro model of HepG2 hepatocarcinoma cells. The expression levels of 96 transcript species implicated in the inflammatory and immune responses was studied after a 24h incubation of HepG2 cells in presence of raw MWCNT dispersed in water by stirring. Among the 46 transcript species detected, only a few transcripts including mRNA coding for interleukine-7, chemokines receptor of the C-C families CCR7, as well as Endothelin-1, were statistically more abundant after treatment with MWCNT. Altogether, these data indicate that MWCNT can only induce a weak inflammatory response in HepG2 cells.
langue originaleAnglais
journalJournal of Physics : Conference Series
Volume304
Numéro de publication1
Les DOIs
Etat de la publicationPublié - 1 janv. 2011

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