Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A

Eduard Dolusic, Pierre Larrieu, Céline Meinguet, Delphine Colette, Arnaud Rives, Sébastien Blanc, Thierry Ferain, Luc Pilotte, Vincent Stroobant, Johan Wouters, Benoît Van den Eynde, Bernard Masereel, Evelyne Delfourne, Raphaël Frédérick

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Résumé

Tsitsikammamines are marine alkaloids whose structure is based on the pyrroloiminoquinone scaffold. These and related compounds have attracted attention due to various interesting biological properties, including cytotoxicity, topoisomerase inhibition, antimicrobial, antifungal and antimalarial activity. Indoleamine 2,3-dioxygenase (IDO1) is a well-established therapeutic target as an important factor in the tumor immune evasion mechanism. In this preliminary communication, we report the inhibitory activity of tsitsikammamine derivatives against IDO1. Tsitsikammamine A analogue 11b displays submicromolar potency in an enzymatic assay. A number of derivatives are also active in a cellular assay while showing little or no activity towards tryptophan 2,3-dioxygenase (TDO), a functionally related enzyme. This IDO1 inhibitory activity is rationalized by molecular modeling studies. An interest is thus established in this class of compounds as a potential source of lead compounds for the development of new pharmaceutically useful IDO1 inhibitors.

langue originaleAnglais
Pages (de - à)47-54
Nombre de pages8
journalBioorganic and medicinal chemistry letters
Volume23
Numéro de publication1
Date de mise en ligne précoce24 nov. 2012
Les DOIs
étatPublié - 1 janv. 2013
EvénementJFB 2011. - Liege, Belgique
Durée: 19 mai 2011 → …

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