In vivo biodistribution of amino-functionalized ceria nanoparticles in rats using positron emission tomography

Santiago Rojas, Juan Domingo Gispert, Sergio Abad, Mireia Buaki-Sogo, Victor M. Victor, Hermenegildo Garcia, Jose Raúl Herance

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

A variety of nanoparticles have been proposed for several biomedical applications. To gauge the therapeutic potential of these nanoparticles, in vivo biodistribution is essential and mandatory. In the present study, ceria nanoparticles (5 nm average particle size) were labeled with 18F to study their in vivo biodistribution in rats by positron emission tomography (PET). The 18F isotope was anchored by reaction of N-succinimidyl 4-[18F]fluorobenzoate (18F-SFB) with a modified nanoparticle surface obtained by silylation with 3-aminopropylsilyl. Radiolabeled ceria nanoparticles accumulated mainly in lungs, spleen, and liver. Metabolic products of the radiolabeled nanoparticulate material were excreted into the urinary tract.

langue originaleAnglais
Pages (de - à)3543-3550
Nombre de pages8
journalMolecular Pharmaceutics
Volume9
Numéro de publication12
Les DOIs
Etat de la publicationPublié - 3 déc. 2012
Modification externeOui

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