@article{51b1a8a55cf6421a8315fd74547d67ff,
title = "In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators",
abstract = "To investigate the mechanisms of action underlying the anti-inflammatory action of aceclofenac in vivo, we studied in vitro the effect of aceclofenac and its main metabolite, 4'-hydroxyaceclofenac, in comparison with diclofenac, another metabolite, on cyclooxygenases activity as well as interleukin-1beta, -6 and -8, nitric oxide, and prostaglandin E2 production by human osteoarthritic and normal articular chondrocytes.",
keywords = "Adult, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Cells, Cultured, Chondrocytes, Cyclooxygenase 1, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Cytokines, DNA, Diclofenac, Dinoprostone, Humans, Inflammation Mediators, Interleukin-1, Isoenzymes, Membrane Proteins, Middle Aged, Nitric Oxide, Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Prostaglandin-Endoperoxide Synthases, Reverse Transcriptase Polymerase Chain Reaction",
author = "Y Henrotin and {de Leval}, X and M Mathy-Hartet and A Mouithys-Mickalad and G Deby-Dupont and Dogn{\'e}, {J M} and J Delarge and Reginster, {J Y}",
year = "2001",
month = aug,
language = "English",
volume = "50",
pages = "391--9",
journal = "Inflammation research : official journal of the European Histamine Research Society ... [et al.]",
issn = "1023-3830",
publisher = "Birkhauser Verlag Basel",
number = "8",
}