Improving nefiracetam dissolution and solubility behavior using a cocrystallization approach

Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens

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    Résumé

    In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).

    langue originaleAnglais
    Numéro d'article653
    Pages (de - à)1-14
    Nombre de pages14
    journalPharmaceutics
    Volume12
    Numéro de publication7
    Les DOIs
    Etat de la publicationPublié - juil. 2020

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