Improving nefiracetam dissolution and solubility behavior using a cocrystallization approach

Xavier Buol; Koen Robeyns; Camila Caro Garrido; Nikolay Tumanov; Laurent Collard; Johan Wouters; Tom Leyssens

doi:10.3390/pharmaceutics12070653

Improving nefiracetam dissolution and solubility behavior using a cocrystallization approach

Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens

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Résumé

In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).

langue originale	Anglais
Numéro d'article	653
Pages (de - à)	1-14
Nombre de pages	14
journal	Pharmaceutics
Volume	12
Numéro de publication	7
Les DOIs	https://doi.org/10.3390/pharmaceutics12070653
Etat de la publication	Publié - juil. 2020

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10.3390/pharmaceutics12070653

2020_TumanovWouters_articleVersion finale publiée, 4,14 MB

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title = "Improving nefiracetam dissolution and solubility behavior using a cocrystallization approach",

abstract = "In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).",

keywords = "Cocrystals, Dissolution rate, Formulation, Nefiracetam, Solid state, Solubility, Stability",

author = "Xavier Buol and Koen Robeyns and Garrido, {Camila Caro} and Nikolay Tumanov and Laurent Collard and Johan Wouters and Tom Leyssens",

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AU - Buol, Xavier

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AU - Garrido, Camila Caro

AU - Tumanov, Nikolay

AU - Collard, Laurent

AU - Wouters, Johan

AU - Leyssens, Tom

PY - 2020/7

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N2 - In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).

AB - In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).

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KW - Dissolution rate

KW - Formulation

KW - Nefiracetam

KW - Solid state

KW - Solubility

KW - Stability

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Improving nefiracetam dissolution and solubility behavior using a cocrystallization approach

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