Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug

Xavier Buol, Koen Robeyns, Nikolay Tumanov, J. Wouters, Tom Leyssens

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.

langue originaleAnglais
Pages (de - à)3616-3622
Nombre de pages7
journalJournal of Pharmaceutical Sciences
Volume108
Numéro de publication11
Date de mise en ligne précoce24 juil. 2019
Les DOIs
Etat de la publicationPublié - 1 nov. 2019

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