Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug

Xavier Buol; Koen Robeyns; Nikolay Tumanov; J. Wouters; Tom Leyssens

doi:10.1016/j.xphs.2019.07.010

Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug

Xavier Buol, Koen Robeyns, Nikolay Tumanov, J. Wouters, Tom Leyssens

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.

langue originale	Anglais
Pages (de - à)	3616-3622
Nombre de pages	7
journal	Journal of Pharmaceutical Sciences
Volume	108
Numéro de publication	11
Date de mise en ligne précoce	24 juil. 2019
Les DOIs	https://doi.org/10.1016/j.xphs.2019.07.010
Etat de la publication	Publié - 1 nov. 2019

Accès au document

10.1016/j.xphs.2019.07.010

Autres fichiers et liens

Link to publication in Scopus

Physico-chimie et caractérisation (PC2)
Wouters, J. (!!Manager), Aprile, C. (!!Manager) & Fusaro, L. (!!Manager)
Plateforme technologique Caracterisation physico-chimiques
Equipement/installations: Plateforme technolgique

Contient cette citation

@article{7100ff8c16f5419cba6c3d675ea7630d,

title = "Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug",

abstract = "In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.",

keywords = "dissolution, formulation, hydrate, nefiracetam, polymorph, solid state",

author = "Xavier Buol and Koen Robeyns and Nikolay Tumanov and J. Wouters and Tom Leyssens",

year = "2019",

month = nov,

day = "1",

doi = "10.1016/j.xphs.2019.07.010",

language = "English",

volume = "108",

pages = "3616--3622",

journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

publisher = "John Wiley and Sons Inc.",

number = "11",

}

TY - JOUR

T1 - Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms

T2 - A Potential Antidementia Drug

AU - Buol, Xavier

AU - Robeyns, Koen

AU - Tumanov, Nikolay

AU - Wouters, J.

AU - Leyssens, Tom

PY - 2019/11/1

Y1 - 2019/11/1

N2 - In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.

AB - In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.

KW - dissolution

KW - formulation

KW - hydrate

KW - nefiracetam

KW - polymorph

KW - solid state

UR - http://www.scopus.com/inward/record.url?scp=85070512848&partnerID=8YFLogxK

U2 - 10.1016/j.xphs.2019.07.010

DO - 10.1016/j.xphs.2019.07.010

M3 - Article

AN - SCOPUS:85070512848

SN - 0022-3549

VL - 108

SP - 3616

EP - 3622

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 11

ER -

Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug

Résumé

Accès au document

Autres fichiers et liens

Empreinte digitale

Équipement

Physico-chimie et caractérisation (PC2)

Contient cette citation