Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug

Xavier Buol, Koen Robeyns, Nikolay Tumanov, J. Wouters, Tom Leyssens

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.

langue originaleAnglais
Pages (de - à)3616-3622
Nombre de pages7
journalJournal of Pharmaceutical Sciences
Volume108
Numéro de publication11
Date de mise en ligne précoce24 juil. 2019
Les DOIs
étatPublié - 1 nov. 2019

Empreinte digitale

Nootropic Agents
Thermodynamics
Solubility
Pharmaceutical Preparations
nefiracetam

Citer ceci

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title = "Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug",
abstract = "In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.",
keywords = "dissolution, formulation, hydrate, nefiracetam, polymorph, solid state",
author = "Xavier Buol and Koen Robeyns and Nikolay Tumanov and J. Wouters and Tom Leyssens",
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Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms : A Potential Antidementia Drug. / Buol, Xavier; Robeyns, Koen; Tumanov, Nikolay; Wouters, J.; Leyssens, Tom.

Dans: Journal of Pharmaceutical Sciences, Vol 108, Numéro 11, 01.11.2019, p. 3616-3622.

Résultats de recherche: Contribution à un journal/une revueArticle

TY - JOUR

T1 - Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms

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AU - Wouters, J.

AU - Leyssens, Tom

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