Hypoxia-induced activation of endothelial cells as a possible cause of venous diseases: Hypothesis

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs


Blood stasis in leg veins is a situation commonly linked to the development of venous diseases such as varicoses. Such a stasis will provoke an ischemia, thus decreasing oxygen availability to tissues. Owing to its localization between blood and tissue, endothelium is the first target of this insult. The authors develop here a hypothesis in which the effect of oxygen deprivation on the functional state of the endothelium is the starting point of a cascade of events leading to the disorganization of the vessel wall typical of these pathologies. When venous human endothelial cells obtained from umbilical cords (HUVEC) are exposed to hypoxic conditions they become activated without change in their viability. The synthesis of a proinflammatory molecule (PAF, platelet-activating factor) and the adhesion of human polymorphonuclear neutrophils (PMN) on HUVEC are markedly increased during hypoxia incubation. These two processes are related to a calcium- dependent activation of endothelial cells due to a decrease of adenosine triphosphate (ATP) availability during hypoxia. Adherence of neutrophils to endothelial cells is the first step of diapedesis, which leads to the infiltration of these cells in the media of the veins, where they affect the smooth muscle cells and the connective tissue, leading to tissue alterations typical of the venous pathologies. The authors propose that this sequential process which originates from a reduction in oxygen availability and which involves different cell types as one main cause of the venous disorders, in addition to genetic, hormonal, and mechanical factors.

langue originaleAnglais
Pages (de - à)639-646
Nombre de pages8
Numéro de publication8
Etat de la publicationPublié - 1993

Empreinte digitale

Examiner les sujets de recherche de « Hypoxia-induced activation of endothelial cells as a possible cause of venous diseases: Hypothesis ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation