Hydrazine selective dual signaling chemodosimetric probe in physiological conditions and its application in live cells

Sandip Nandi, Animesh Sahana, Sandip Mandal, Archya Sengupta, Ansuman Chatterjee, Damir A. Safin, Maria G. Babashkina, Nikolay A. Tumanov, Yaroslav Filinchuk, Debasis Das

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Résumé

A rhodamine-cyanobenzene conjugate, (E)-4-((2-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthene]-2-yl)ethylimino)methyl)benzonitrile (1), which structure has been elucidated by single crystal X-ray diffraction, was synthesized for selective fluorescent "turn-on" and colorimetric recognition of hydrazine at physiological pH 7.4. It was established that 1 detects hydrazine up to 58 nM. The probe is useful for the detection of intracellular hydrazine in the human breast cancer cells MCF-7 using a fluorescence microscope. Spirolactam ring opening of 1, followed by its hydrolysis, was established as a probable mechanism for the selective sensing of hydrazine.
langue originaleAnglais
Pages (de - à)84-90
Nombre de pages7
journalAnalytica chimica acta
Volume893
Les DOIs
Etat de la publicationPublié - 2015
Modification externeOui

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