TY - JOUR
T1 - Human DNA (cytosine-5)-methyltransferases
T2 - a functional and structural perspective for epigenetic cancer therapy
AU - Rondelet, Grégoire
A2 - Wouters, Johan
N1 - Funding Information:
This work was supported by the Belgian National Fund for Scientific Research (Grant F.R.S. ? FNRS ? T?l?vie 7.4.532.15.F.).
Publisher Copyright:
© 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Epigenetic modifications modulate chromatin states to regulate gene expression. Among them, DNA methylation and histone modifications play a crucial role in the establishment of the epigenome. In cancer, these epigenetic events may act in concert to repress tumor suppressor genes or promote oncogenic pathways. In the context of cancer initiation and progression, recruitment of DNA (cytosine-5)-methyltransferases to specific genomic regions is mainly mediated by histone epigenetic marks, transcription factors and co-regulators as part of a dynamic process. Herein, we will review these mechanisms and present state-of-the-art of DNA methylation, treatment and development of epigenetic cancer therapies targeting this epigenetic modification.
AB - Epigenetic modifications modulate chromatin states to regulate gene expression. Among them, DNA methylation and histone modifications play a crucial role in the establishment of the epigenome. In cancer, these epigenetic events may act in concert to repress tumor suppressor genes or promote oncogenic pathways. In the context of cancer initiation and progression, recruitment of DNA (cytosine-5)-methyltransferases to specific genomic regions is mainly mediated by histone epigenetic marks, transcription factors and co-regulators as part of a dynamic process. Herein, we will review these mechanisms and present state-of-the-art of DNA methylation, treatment and development of epigenetic cancer therapies targeting this epigenetic modification.
KW - DNA methylation
KW - Promoter methylation
KW - Gene body methylation
KW - protein-protein interaction
KW - DNMT inhibitors
KW - Epigenetic therapy
KW - Protein-protein interaction
UR - http://www.scopus.com/inward/record.url?scp=85020750618&partnerID=8YFLogxK
U2 - 10.1016/j.biochi.2017.06.003
DO - 10.1016/j.biochi.2017.06.003
M3 - Article
VL - 139
SP - 137
EP - 147
JO - Biochimie
JF - Biochimie
SN - 0300-9084
M1 - 139
ER -