Human DNA (cytosine-5)-methyltransferases: a functional and structural perspective for epigenetic cancer therapy

Grégoire Rondelet, Johan Wouters (Promoteur)

Résultats de recherche: Contribution à un journal/une revue › Article de revue

Résumé

Epigenetic modifications modulate chromatin states to regulate gene expression. Among them, DNA methylation and histone modifications play a crucial role in the establishment of the epigenome. In cancer, these epigenetic events may act in concert to repress tumor suppressor genes or promote oncogenic pathways. In the context of cancer initiation and progression, recruitment of DNA (cytosine-5)-methyltransferases to specific genomic regions is mainly mediated by histone epigenetic marks, transcription factors and co-regulators as part of a dynamic process. Herein, we will review these mechanisms and present state-of-the-art of DNA methylation, treatment and development of epigenetic cancer therapies targeting this epigenetic modification.
langueAnglais
Numéro d'article139
Pages137-147
Nombre de pages11
journalBiochimie
Les DOIs
étatPublié - 2017

Empreinte digitale

DNA (Cytosine-5-)-Methyltransferase
Epigenomics
Histones
Histone Code
Gene expression
Chromatin
Tumors
DNA Methylation
Neoplasms
Transcription Factors
Genes
Therapeutics
Tumor Suppressor Genes
Gene Expression

mots-clés

    Citer ceci

    Rondelet, Grégoire ; Wouters, Johan. / Human DNA (cytosine-5)-methyltransferases : a functional and structural perspective for epigenetic cancer therapy. Dans: Biochimie. 2017 ; p. 137-147
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    abstract = "Epigenetic modifications modulate chromatin states to regulate gene expression. Among them, DNA methylation and histone modifications play a crucial role in the establishment of the epigenome. In cancer, these epigenetic events may act in concert to repress tumor suppressor genes or promote oncogenic pathways. In the context of cancer initiation and progression, recruitment of DNA (cytosine-5)-methyltransferases to specific genomic regions is mainly mediated by histone epigenetic marks, transcription factors and co-regulators as part of a dynamic process. Herein, we will review these mechanisms and present state-of-the-art of DNA methylation, treatment and development of epigenetic cancer therapies targeting this epigenetic modification.",
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    Rondelet, G & Wouters, J 2017, 'Human DNA (cytosine-5)-methyltransferases: a functional and structural perspective for epigenetic cancer therapy' Biochimie, p. 137-147. DOI: 10.1016/j.biochi.2017.06.003

    Human DNA (cytosine-5)-methyltransferases : a functional and structural perspective for epigenetic cancer therapy. / Rondelet, Grégoire; Wouters, Johan (Promoteur).

    Dans: Biochimie, 2017, p. 137-147.

    Résultats de recherche: Contribution à un journal/une revue › Article de revue

    TY - JOUR

    T1 - Human DNA (cytosine-5)-methyltransferases

    T2 - Biochimie

    AU - Rondelet,Grégoire

    A2 - Wouters,Johan

    PY - 2017

    Y1 - 2017

    N2 - Epigenetic modifications modulate chromatin states to regulate gene expression. Among them, DNA methylation and histone modifications play a crucial role in the establishment of the epigenome. In cancer, these epigenetic events may act in concert to repress tumor suppressor genes or promote oncogenic pathways. In the context of cancer initiation and progression, recruitment of DNA (cytosine-5)-methyltransferases to specific genomic regions is mainly mediated by histone epigenetic marks, transcription factors and co-regulators as part of a dynamic process. Herein, we will review these mechanisms and present state-of-the-art of DNA methylation, treatment and development of epigenetic cancer therapies targeting this epigenetic modification.

    AB - Epigenetic modifications modulate chromatin states to regulate gene expression. Among them, DNA methylation and histone modifications play a crucial role in the establishment of the epigenome. In cancer, these epigenetic events may act in concert to repress tumor suppressor genes or promote oncogenic pathways. In the context of cancer initiation and progression, recruitment of DNA (cytosine-5)-methyltransferases to specific genomic regions is mainly mediated by histone epigenetic marks, transcription factors and co-regulators as part of a dynamic process. Herein, we will review these mechanisms and present state-of-the-art of DNA methylation, treatment and development of epigenetic cancer therapies targeting this epigenetic modification.

    KW - DNA methylation

    KW - Promoter methylation

    KW - Gene body methylation

    KW - protein-protein interaction

    KW - DNMT inhibitors

    KW - Epigenetic therapy

    U2 - 10.1016/j.biochi.2017.06.003

    DO - 10.1016/j.biochi.2017.06.003

    M3 - Review article

    SP - 137

    EP - 147

    JO - Biochimie

    JF - Biochimie

    SN - 0300-9084

    M1 - 139

    ER -

    Rondelet G, Wouters J. Human DNA (cytosine-5)-methyltransferases: a functional and structural perspective for epigenetic cancer therapy. Biochimie. 2017;137-147. 139. Disponible �, DOI: 10.1016/j.biochi.2017.06.003

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