Résumé
WI-38 human diploid fibroblasts underwent accelerated telomere shortening (490 bp/stress) and growth arrest after exposure to four subcytotoxic 100 μM tert-butylhydroperoxide (t-BHP) stresses, with a stress at every two population doublings (PD). After subcytotoxic 160 μM HO stress or five repeated 30 μM t-BHP stresses along the same PD, respectively a 322±55 and 380±129 bp telomere shortening was observed only during the first PD after stress. The percentage of cells resuming proliferation after stress suggests this telomere shortening is due to the number of cell divisions accomplished to reach confluence during the first PD after stress.
langue originale | Anglais |
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Pages (de - à) | 109-112 |
Nombre de pages | 4 |
journal | FEBS Letters |
Volume | 502 |
Numéro de publication | 3 |
Les DOIs | |
Etat de la publication | Publié - 3 août 2001 |