Résumé
Design of multivalent glycoconjugates can find applications such as in anti-adhesive therapy against bacterial infections. Nevertheless, the access to such macromolecules requires functionalized building blocks prepared in a minimum number of steps and on a multi-gram scale at least for the laboratory. Fucose is a representative epitope used by several bacteria for adhesion to their host cells. The stereoselective, rapid, and efficient access to two 'clickable' α-fucosides was re-investigated using PPh3/CBr 4-promoted glycosylation of chloro- (as precursors of azido-) and alkyne-functionalized triethyleneglycols with fully unprotected l-fucose. The convenient access to such building blocks paves the way to the design of new multivalent glycoconjugates functionalized with fucose epitopes and their applications.
langue originale | Anglais |
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Pages (de - à) | 15-18 |
Nombre de pages | 4 |
journal | Carbohydrate Research |
Volume | 395 |
Les DOIs | |
Etat de la publication | Publié - 18 août 2014 |
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Physico-chimie et caractérisation (PC2)
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