Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

Kévin Buffet; Emilie Gillon; Michel Holler; Jean François Nierengarten; Anne Imberty; Stéphane Vincent

doi:10.1039/c5ob00689a

Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

Kévin Buffet, Emilie Gillon, Michel Holler, Jean François Nierengarten, Anne Imberty, Stéphane Vincent

Unite de recherche en chimie organique

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

A series of water-soluble glycofullerenes containing up to 24 fucose residues have been prepared. These compounds were tested against the two bacterial fucose-binding lectins LecB and RSL, and C₆₀(E)₁₂ bearing 24 fucose residues appeared to be the best known inhibitor of both lectins to date. We have shown that increasing both the valency and the length of the spacer between the central core and the peripheral sugars can be beneficial for the affinity.

langue originale	Anglais
Pages (de - à)	6482-6492
Nombre de pages	11
journal	Organic and Biomolecular Chemistry
Volume	13
Numéro de publication	23
Les DOIs	https://doi.org/10.1039/c5ob00689a
Etat de la publication	Publié - 21 juin 2015

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abstract = "A series of water-soluble glycofullerenes containing up to 24 fucose residues have been prepared. These compounds were tested against the two bacterial fucose-binding lectins LecB and RSL, and C60(E)12 bearing 24 fucose residues appeared to be the best known inhibitor of both lectins to date. We have shown that increasing both the valency and the length of the spacer between the central core and the peripheral sugars can be beneficial for the affinity.",

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AU - Buffet, Kévin

AU - Gillon, Emilie

AU - Holler, Michel

AU - Nierengarten, Jean François

AU - Imberty, Anne

AU - Vincent, Stéphane

PY - 2015/6/21

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AB - A series of water-soluble glycofullerenes containing up to 24 fucose residues have been prepared. These compounds were tested against the two bacterial fucose-binding lectins LecB and RSL, and C60(E)12 bearing 24 fucose residues appeared to be the best known inhibitor of both lectins to date. We have shown that increasing both the valency and the length of the spacer between the central core and the peripheral sugars can be beneficial for the affinity.

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ER -

Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

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