Fatty acid amide hydrolase: from characterization to therapeutics

Geoffray Labar, Catherine Michaux

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs


Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme within the amidase-signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. The hydrolysis of such messengers leads to molecules devoid of biological activity, and, therefore, modulates a number of neurobehavioral processes in mammals, including pain, sleep, feeding, and locomotor activity. Investigations into the structure and function of FAAH, its biological and therapeutic implications, as well as a description of different families of FAAH inhibitors are the topic of this review.
langue originaleAnglais
Pages (de - à)1882-1902
Nombre de pages21
journalChemistry & biodiversity
Numéro de publication8
Les DOIs
Etat de la publicationPublié - 2007

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