Fast, asymmetric and nonhomogeneous clearance of SiC nanoaerosol assessed by micro-particle-induced x-ray emission

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Aim: To study the biopersistence of a silicon carbide (SiC) nanoaerosol in rat lungs, as time-dependent clearance and spatial distribution. Materials & methods: Sprague-Dawley rats were exposed 6 h/day during 5 days to a SiC nanoaerosol at 4.91 mg SiC/l. SiC biopersistence in rat lungs sections was assessed over 28 days by micro-particle-induced x-ray emission (μPIXE) as 2D maps and by particle-induced x-ray emission (PIXE) for whole-lung quantification. 2D maps were analyzed for SiC spatial distribution as skewness and kurtosis. Results: Half-Time clearance was 10.9 ± 0.9 days, agreeing with PIXE measurements. Spatialtemporal analysis of SiC indicated decreased symmetry and homogeneity. Conclusion: Fast SiC clearance points that current nanoaerosol exposuremay not be enough to trigger lung overload. Spatial distribution shows an asymmetric and nonhomogeneous SiC clearance.

langue originaleAnglais
Nombre de pages12
journalNanomedicine
Volume13
Numéro de publication2
Les DOIs
étatPublié - 1 janv. 2018

Empreinte digitale

Silicon carbide
silicon
X-Rays
X rays
Spatial distribution
quantification
Rats
Lung
spatial distribution
particle
silicon carbide
skewness
homogeneity
Sprague Dawley Rats
symmetry
time

Citer ceci

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title = "Fast, asymmetric and nonhomogeneous clearance of SiC nanoaerosol assessed by micro-particle-induced x-ray emission",
abstract = "Aim: To study the biopersistence of a silicon carbide (SiC) nanoaerosol in rat lungs, as time-dependent clearance and spatial distribution. Materials & methods: Sprague-Dawley rats were exposed 6 h/day during 5 days to a SiC nanoaerosol at 4.91 mg SiC/l. SiC biopersistence in rat lungs sections was assessed over 28 days by micro-particle-induced x-ray emission (μPIXE) as 2D maps and by particle-induced x-ray emission (PIXE) for whole-lung quantification. 2D maps were analyzed for SiC spatial distribution as skewness and kurtosis. Results: Half-Time clearance was 10.9 ± 0.9 days, agreeing with PIXE measurements. Spatialtemporal analysis of SiC indicated decreased symmetry and homogeneity. Conclusion: Fast SiC clearance points that current nanoaerosol exposuremay not be enough to trigger lung overload. Spatial distribution shows an asymmetric and nonhomogeneous SiC clearance.",
keywords = "Biopersistence, Particle-induced x-ray emission, Rat lungs, SiC nanoparticles, μPIXE",
author = "Omar Lozano and Colaux, {Julien L.} and Julie Laloy and L{\"u}tfiye Alpan and Dogn{\'e}, {Jean Michel} and Stephane Lucas",
year = "2018",
month = "1",
day = "1",
doi = "10.2217/nnm-2017-0245",
language = "English",
volume = "13",
journal = "Nanomedicine",
issn = "1743-5889",
publisher = "Future Medicine Ltd.",
number = "2",

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TY - JOUR

T1 - Fast, asymmetric and nonhomogeneous clearance of SiC nanoaerosol assessed by micro-particle-induced x-ray emission

AU - Lozano, Omar

AU - Colaux, Julien L.

AU - Laloy, Julie

AU - Alpan, Lütfiye

AU - Dogné, Jean Michel

AU - Lucas, Stephane

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Aim: To study the biopersistence of a silicon carbide (SiC) nanoaerosol in rat lungs, as time-dependent clearance and spatial distribution. Materials & methods: Sprague-Dawley rats were exposed 6 h/day during 5 days to a SiC nanoaerosol at 4.91 mg SiC/l. SiC biopersistence in rat lungs sections was assessed over 28 days by micro-particle-induced x-ray emission (μPIXE) as 2D maps and by particle-induced x-ray emission (PIXE) for whole-lung quantification. 2D maps were analyzed for SiC spatial distribution as skewness and kurtosis. Results: Half-Time clearance was 10.9 ± 0.9 days, agreeing with PIXE measurements. Spatialtemporal analysis of SiC indicated decreased symmetry and homogeneity. Conclusion: Fast SiC clearance points that current nanoaerosol exposuremay not be enough to trigger lung overload. Spatial distribution shows an asymmetric and nonhomogeneous SiC clearance.

AB - Aim: To study the biopersistence of a silicon carbide (SiC) nanoaerosol in rat lungs, as time-dependent clearance and spatial distribution. Materials & methods: Sprague-Dawley rats were exposed 6 h/day during 5 days to a SiC nanoaerosol at 4.91 mg SiC/l. SiC biopersistence in rat lungs sections was assessed over 28 days by micro-particle-induced x-ray emission (μPIXE) as 2D maps and by particle-induced x-ray emission (PIXE) for whole-lung quantification. 2D maps were analyzed for SiC spatial distribution as skewness and kurtosis. Results: Half-Time clearance was 10.9 ± 0.9 days, agreeing with PIXE measurements. Spatialtemporal analysis of SiC indicated decreased symmetry and homogeneity. Conclusion: Fast SiC clearance points that current nanoaerosol exposuremay not be enough to trigger lung overload. Spatial distribution shows an asymmetric and nonhomogeneous SiC clearance.

KW - Biopersistence

KW - Particle-induced x-ray emission

KW - Rat lungs

KW - SiC nanoparticles

KW - μPIXE

UR - http://www.scopus.com/inward/record.url?scp=85048855027&partnerID=8YFLogxK

U2 - 10.2217/nnm-2017-0245

DO - 10.2217/nnm-2017-0245

M3 - Article

VL - 13

JO - Nanomedicine

JF - Nanomedicine

SN - 1743-5889

IS - 2

ER -