Fast, asymmetric and nonhomogeneous clearance of SiC nanoaerosol assessed by micro-particle-induced x-ray emission

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Résumé

Aim: To study the biopersistence of a silicon carbide (SiC) nanoaerosol in rat lungs, as time-dependent clearance and spatial distribution. Materials & methods: Sprague-Dawley rats were exposed 6 h/day during 5 days to a SiC nanoaerosol at 4.91 mg SiC/l. SiC biopersistence in rat lungs sections was assessed over 28 days by micro-particle-induced x-ray emission (μPIXE) as 2D maps and by particle-induced x-ray emission (PIXE) for whole-lung quantification. 2D maps were analyzed for SiC spatial distribution as skewness and kurtosis. Results: Half-Time clearance was 10.9 ± 0.9 days, agreeing with PIXE measurements. Spatialtemporal analysis of SiC indicated decreased symmetry and homogeneity. Conclusion: Fast SiC clearance points that current nanoaerosol exposuremay not be enough to trigger lung overload. Spatial distribution shows an asymmetric and nonhomogeneous SiC clearance.

langue originaleAnglais
Nombre de pages12
journalNanomedicine
Volume13
Numéro de publication2
Les DOIs
étatPublié - 1 janv. 2018

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