TY - JOUR
T1 - Extracellular Vesicles in Red Blood Cell Concentrates
T2 - An Overview
AU - Wannez, Adeline
AU - Devalet, Bérangère
AU - Chatelain, Bernard
AU - Chatelain, Christian
AU - Dogné, Jean-Michel
AU - Mullier, François
N1 - Copyright © 2019 Elsevier Inc. All rights reserved.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.
AB - Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.
KW - Blood transfusions
KW - Extracellular vesicles
KW - Microparticles
KW - Red blood cell concentrate
UR - http://www.scopus.com/inward/record.url?scp=85063208767&partnerID=8YFLogxK
U2 - 10.1016/j.tmrv.2019.02.002
DO - 10.1016/j.tmrv.2019.02.002
M3 - Review article
C2 - 30910256
AN - SCOPUS:85063208767
SN - 0887-7963
VL - 33
SP - 125
EP - 130
JO - Transfusion Medicine Reviews
JF - Transfusion Medicine Reviews
IS - 2
ER -