Evaluation of metal trace detachment from dosing pumps using PIXE

Omar Lozano Garcia; Jorge Humberto Mejia Mendoza; Julie Laloy; Lütfiye Alpan; Olivier Toussaint; Jean-Michel Dogne; Stéphane Lucas

doi:10.1016/j.nimb.2014.01.006

Evaluation of metal trace detachment from dosing pumps using PIXE

Omar Lozano Garcia, Jorge Humberto Mejia Mendoza, Julie Laloy, Lütfiye Alpan, Olivier Toussaint, Jean-Michel Dogne, Stéphane Lucas

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

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Résumé

Metal trace detachment evaluation is essential for instruments destined for pharmaceutical applications, such as pumps. Particle-Induced X-ray Emission (PIXE) was used to determine and quantify metal traces originated from stainless steel and ceramic dosing pumps. Metal traces were quantified from either distilled water samples or cellulose filters in two tests: a short-term test of 16 h mimicking a daily cycle of a dosing pump for industrial applications, and a long-term test of 9 days evaluating the pump wearing. The main result is that ceramic dosing pumps present lower metal detachment than stainless steel counterparts. Traces of Si and Al were found originating from pieces around the pumps (pipes and joints).

langue originale	Anglais
journal	Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Les DOIs	https://doi.org/10.1016/j.nimb.2014.01.006
Etat de la publication	Accepté/sous presse - 31 janv. 2014

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10.1016/j.nimb.2014.01.006

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@article{2232314a736640c8b893b729476a3bcc,

title = "Evaluation of metal trace detachment from dosing pumps using PIXE",

abstract = "Metal trace detachment evaluation is essential for instruments destined for pharmaceutical applications, such as pumps. Particle-Induced X-ray Emission (PIXE) was used to determine and quantify metal traces originated from stainless steel and ceramic dosing pumps. Metal traces were quantified from either distilled water samples or cellulose filters in two tests: a short-term test of 16 h mimicking a daily cycle of a dosing pump for industrial applications, and a long-term test of 9 days evaluating the pump wearing. The main result is that ceramic dosing pumps present lower metal detachment than stainless steel counterparts. Traces of Si and Al were found originating from pieces around the pumps (pipes and joints).",

keywords = "Ceramic, Dosing pump, Metal trace, PIXE, Stainless steel",

author = "{Lozano Garcia}, Omar and {Mejia Mendoza}, {Jorge Humberto} and Julie Laloy and L{\"u}tfiye Alpan and Olivier Toussaint and Jean-Michel Dogne and St{\'e}phane Lucas",

year = "2014",

month = jan,

day = "31",

doi = "10.1016/j.nimb.2014.01.006",

language = "English",

journal = "Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms",

issn = "0168-583X",

publisher = "Elsevier",

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TY - JOUR

T1 - Evaluation of metal trace detachment from dosing pumps using PIXE

AU - Lozano Garcia, Omar

AU - Mejia Mendoza, Jorge Humberto

AU - Laloy, Julie

AU - Alpan, Lütfiye

AU - Toussaint, Olivier

AU - Dogne, Jean-Michel

AU - Lucas, Stéphane

PY - 2014/1/31

Y1 - 2014/1/31

N2 - Metal trace detachment evaluation is essential for instruments destined for pharmaceutical applications, such as pumps. Particle-Induced X-ray Emission (PIXE) was used to determine and quantify metal traces originated from stainless steel and ceramic dosing pumps. Metal traces were quantified from either distilled water samples or cellulose filters in two tests: a short-term test of 16 h mimicking a daily cycle of a dosing pump for industrial applications, and a long-term test of 9 days evaluating the pump wearing. The main result is that ceramic dosing pumps present lower metal detachment than stainless steel counterparts. Traces of Si and Al were found originating from pieces around the pumps (pipes and joints).

AB - Metal trace detachment evaluation is essential for instruments destined for pharmaceutical applications, such as pumps. Particle-Induced X-ray Emission (PIXE) was used to determine and quantify metal traces originated from stainless steel and ceramic dosing pumps. Metal traces were quantified from either distilled water samples or cellulose filters in two tests: a short-term test of 16 h mimicking a daily cycle of a dosing pump for industrial applications, and a long-term test of 9 days evaluating the pump wearing. The main result is that ceramic dosing pumps present lower metal detachment than stainless steel counterparts. Traces of Si and Al were found originating from pieces around the pumps (pipes and joints).

KW - Ceramic

KW - Dosing pump

KW - Metal trace

KW - PIXE

KW - Stainless steel

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DO - 10.1016/j.nimb.2014.01.006

M3 - Article

SN - 0168-583X

JO - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

ER -

Evaluation of metal trace detachment from dosing pumps using PIXE

Résumé

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