TY - JOUR
T1 - Evaluation of BM-573, a novel TXA2 synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion
AU - Kolh, Philippe
AU - Rolin, Stéphanie
AU - Tchana-Sato, Vincent
AU - Pétein, Michel
AU - Ghuysen, Alexandre
AU - Lambermont, Bernard
AU - Hanson, Julien
AU - Magis, David
AU - Segers, Patrick
AU - Masereel, Bernard
AU - D'Orio, Vincent
AU - Dogne, Jean-Michel
PY - 2006/3
Y1 - 2006/3
N2 - To investigate whether BM-573 (N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea), an original combined thromboxane A2 synthase inhibitor and receptor antagonist, prevents reperfusion injury in acutely ischemic pigs.
AB - To investigate whether BM-573 (N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea), an original combined thromboxane A2 synthase inhibitor and receptor antagonist, prevents reperfusion injury in acutely ischemic pigs.
KW - Animals
KW - Blood Pressure
KW - Cardiac Output
KW - Disease Models, Animal
KW - Drug Evaluation, Preclinical
KW - Female
KW - Infusions, Intravenous
KW - Male
KW - Myocardial Reperfusion Injury
KW - Receptors, Thromboxane
KW - Sulfonylurea Compounds
KW - Swine
KW - Thromboxane-A Synthase
KW - Ventricular Function, Left
U2 - 10.1016/j.prostaglandins.2005.10.002
DO - 10.1016/j.prostaglandins.2005.10.002
M3 - Article
C2 - 16516810
SN - 1098-8823
VL - 79
SP - 53
EP - 73
JO - Prostaglandins and Other Lipid Mediators
JF - Prostaglandins and Other Lipid Mediators
IS - 1-2
ER -