Epidermal hyaluronan in barrier alteration-related disease

Résultats de recherche: Contribution à un journal/une revueArticle de revueRevue par des pairs


In skin, although the extracellular matrix (ECM) is highly developed in dermis and hypodermis, discrete intercellular spaces between cells of the living epidermal layers are also filled with ECM components. Herein, we review knowledge about structure, localization and role of epidermal hyaluronan (HA), a key ECM molecule. HA is a non-sulfated glycosaminoglycan non-covalently bound to proteins or lipids. Components of the basal lamina maintain some segregation between the epidermis and the underlying dermis, and all epidermal HA is locally synthesized and degraded. Functions of HA in keratinocyte proliferation and differentiation are still controversial. However, through interactions with partners, such as the TSG-6 protein, HA is involved in the formation, organization and stabilization of the epidermal ECM. In addition, epidermal HA is involved in the formation of an efficient epidermal barrier made of cornified keratinocytes. In atopic dermatitis (AD) with profuse alterations of the epidermal barrier, HA is produced in larger amounts by keratinocytes than in normal skin. Epidermal HA inside AD lesional skin is located in enlarged intercellular spaces, likely as the result of disease-related modifications of HA metabolism.

langue originaleAnglais
Numéro d'article3096
Nombre de pages18
Numéro de publication11
Les DOIs
Etat de la publicationPublié - 9 nov. 2021

Empreinte digitale

Examiner les sujets de recherche de « Epidermal hyaluronan in barrier alteration-related disease ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation