Homocysteine, derived from the metabolism of methionine, is claimed as a proatherogenic factor that leads to vascular dysfunction. To gain better insight into the molecular mechanisms involved, homocysteine was tested on a model of murine endothelial cells cultured in vitro, using a proto-type DNA chip. The DNA chip was designed to follow the expression at the mRNA level of some major proinflammatory genes; TNF-α was used as a positive control.
|Pages (de - à)||550-554|
|Nombre de pages||5|
|journal||Annals of the New York academy of sciences|
|Etat de la publication||Publié - 2002|