Effects of homocysteine on the cellular responses of murine endothelial cells cultured in vitro

A. Tacheny, Sofia Dos Santos Mendes, A. C. Huet, M. Van Steenbrugge, C. Michiels, P. Holvoet, Martine Raes

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Homocysteine, derived from the metabolism of methionine, is claimed as a proatherogenic factor that leads to vascular dysfunction. To gain better insight into the molecular mechanisms involved, homocysteine was tested on a model of murine endothelial cells cultured in vitro, using a proto-type DNA chip. The DNA chip was designed to follow the expression at the mRNA level of some major proinflammatory genes; TNF-α was used as a positive control.

langue originaleAnglais
Pages (de - à)550-554
Nombre de pages5
journalAnnals of the New York academy of sciences
Volume973
Etat de la publicationPublié - 2002

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