Résumé
Thromboxane A2 is considered to be partially responsible for the increase in pulmonary vascular resistance observed after endotoxin administration and to participate in proinflammatory reactions. The effects of a novel dual TXA2 synthase inhibitor and TXA2 receptor antagonist (BM-573) on pulmonary hemodynamics were investigated in endotoxic shock. 30 mins before the start of a 0.5 mg/kg endotoxin infusion, 6 pigs (Endo group) received a placebo infusion and 6 other pigs (Anta group) received a BM-573 infusion. In Endo group, pulmonary artery pressure increased from 25 +/- 1.8 (T0) to 42 +/- 2.3 mmHg (T60) (p
langue originale | Anglais |
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Pages (de - à) | 224-31 |
Nombre de pages | 8 |
journal | Archives of Physiology and Biochemistry |
Volume | 111 |
Numéro de publication | 3 |
Les DOIs | |
Etat de la publication | Publié - juil. 2003 |