Effects of BM-573, a novel thromboxane A2 inhibitor, on pulmonary hemodynamics in endotoxic shock

B Lambermont, A Ghuysen, J-M Dogné, P Kolh, V Tchana-Sato, P Morimont, P Benoit, P Gérard, B Masereel, V D'Orio

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Thromboxane A2 is considered to be partially responsible for the increase in pulmonary vascular resistance observed after endotoxin administration and to participate in proinflammatory reactions. The effects of a novel dual TXA2 synthase inhibitor and TXA2 receptor antagonist (BM-573) on pulmonary hemodynamics were investigated in endotoxic shock. 30 mins before the start of a 0.5 mg/kg endotoxin infusion, 6 pigs (Endo group) received a placebo infusion and 6 other pigs (Anta group) received a BM-573 infusion. In Endo group, pulmonary artery pressure increased from 25 +/- 1.8 (T0) to 42 +/- 2.3 mmHg (T60) (p
langue originaleAnglais
Pages (de - à)224-31
Nombre de pages8
journalArchives of Physiology and Biochemistry
Volume111
Numéro de publication3
Les DOIs
Etat de la publicationPublié - juil. 2003

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