Does an interaction exist between ketamine hydrochloride and Becton Dickinson syringes?

M. Closset, J. D. Hecq, E. Gonzalez, B. Bihin, J. Jamart, L. Galanti

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Introduction An international alert from Becton Dickinson (BD) has noted the possibility of interaction between several molecules and some syringes. The Centralized IntraVenous Additives Service of the institution was using 3 mL BD syringes to store ketamine HCl. This study evaluated the interaction between ketamine and these syringes. Method A batch of BD syringes produced in Europe and left in quarantine from the day of the international alert has been tested at 22, 29, 36, 43 and 50 days of storage at room temperature. At each time, the pH of the solutions was measured. The solutions were inspected visually and by microscope, and spectrophotometric measurements were performed. The concentrations were measured by a validated ultra-high-performance liquid chromatography-diode array detector. Results Neither physical change nor pH modification was observed during the study. According to a lower limit of the 95% unilateral CI on the mean >90% of the theoretical concentration, the solutions remain stable for at least 50 days. Conclusion In our study conditions, ketamine can be stored for at least 50 days without risk of sorption with syringes.

langue originaleAnglais
Pages (de - à)230-234
Nombre de pages5
journalEuropean Journal of Hospital Pharmacy
Volume24
Numéro de publication4
Les DOIs
Etat de la publicationPublié - 1 juil. 2017
Modification externeOui

Empreinte digitale

Examiner les sujets de recherche de « Does an interaction exist between ketamine hydrochloride and Becton Dickinson syringes? ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation