TY - JOUR
T1 - Differences in the cellular location of substances endocytosed by rat liver as observed from the distribution patterns obtained after isopycnic centrifugation in a sucrose gradient
AU - Wattiaux, Robert
AU - Jadot, Michel
AU - Misquith, Sandra
AU - Dubois, Franz
AU - Wattiaux-De Coninck, Simone
PY - 1986/4/29
Y1 - 1986/4/29
N2 - We have investigated the distribution of several substances endocytosed by rat-liver, after isopycnic centrifugation in a sucrose gradient of the MLP fractions (de Duve, Pressman, Gianetto, Wattiaux and Applemans (1955) Biochem. J. 63, 604-617) isolated at increasing times after injection. It has been observed that there are changes in the distribution pattern with time depending on whether the substance is taken up by parenchymal or sinusoidal cells. The results suggest that centrifugation experiments can be informative with respect to the cellular location of a molecule endocytosed by the liver.
AB - We have investigated the distribution of several substances endocytosed by rat-liver, after isopycnic centrifugation in a sucrose gradient of the MLP fractions (de Duve, Pressman, Gianetto, Wattiaux and Applemans (1955) Biochem. J. 63, 604-617) isolated at increasing times after injection. It has been observed that there are changes in the distribution pattern with time depending on whether the substance is taken up by parenchymal or sinusoidal cells. The results suggest that centrifugation experiments can be informative with respect to the cellular location of a molecule endocytosed by the liver.
UR - http://www.scopus.com/inward/record.url?scp=0022496932&partnerID=8YFLogxK
M3 - Article
C2 - 2423084
AN - SCOPUS:0022496932
SN - 0006-291X
VL - 136
SP - 504
EP - 509
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -