Development of a chitosan nanofibrillar scaffold for skin repair and regeneration

Victor T Tchemtchoua, Ganka Atanasova, Abdel Aqil, Patrice Filée, Nancy Garbacki, Olivier Vanhooteghem, Christophe Deroanne, Agnès Noël, Christine Jérome, Betty Nusgens, Yves Poumay, Alain Colige

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs


The final goal of the present study was the development of a 3-D chitosan dressing that would shorten the healing time of skin wounds by stimulating migration, invasion, and proliferation of the relevant cutaneous resident cells. Three-dimensional chitosan nanofibrillar scaffolds produced by electrospinning were compared with evaporated films and freeze-dried sponges for their biological properties. The nanofibrillar structure strongly improved cell adhesion and proliferation in vitro. When implanted in mice, the nanofibrillar scaffold was colonized by mesenchymal cells and blood vessels. Accumulation of collagen fibrils was also observed. In contrast, sponges induced a foreign body granuloma. When used as a dressing covering full-thickness skin wounds in mice, chitosan nanofibrils induced a faster regeneration of both the epidermis and dermis compartments. Altogether our data illustrate the critical importance of the nanofibrillar structure of chitosan devices for their full biocompatibility and demonstrate the significant beneficial effect of chitosan as a wound-healing biomaterial.
langue originaleAnglais
Pages (de - à)3194-204
Nombre de pages11
Numéro de publication9
Les DOIs
Etat de la publicationPublié - 2011

Empreinte digitale

Examiner les sujets de recherche de « Development of a chitosan nanofibrillar scaffold for skin repair and regeneration ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation