@article{eba95dddc7bd4298879828fc35b7e823,
title = "Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine",
abstract = "Melanoma antigen genes (Mage) were first described as tumour markers. However, some of Mage are also expressed in healthy cells where their functions remain poorly understood. Here, we describe an unexpected role for one of these genes, Maged1, in the control of behaviours related to drug addiction. Mice lacking Maged1 are insensitive to the behavioural effects of cocaine as assessed by locomotor sensitization, conditioned place preference (CPP) and drug self-administration. Electrophysiological experiments in brain slices and conditional knockout mice demonstrate that Maged1 is critical for cortico-accumbal neurotransmission. Further, expression of Maged1 in the prefrontal cortex (PFC) and the amygdala, but not in dopaminergic or striatal and other GABAergic neurons, is necessary for cocaine-mediated behavioural sensitization, and its expression in the PFC is also required for cocaine-induced extracellular dopamine (DA) release in the nucleus accumbens (NAc). This work identifies Maged1 as a critical molecule involved in cellular processes and behaviours related to addiction.",
keywords = "amygdala, dopamine, drug sensitization, nucleus accumbens, prefrontal cortex",
author = "{De Backer}, Jean-Fran{\c c}ois and St{\'e}phanie Monlezun and B{\'e}rang{\`e}re Detraux and Adeline Gazan and Laura Vanopdenbosch and Julian Cheron and Giuseppe Cannazza and S{\'e}bastien Valverde and L{\'i}dia Cantacorps and M{\'e}rie Nassar and Laurent Venance and Olga Valverde and Philippe Faure and Michele Zoli and {De Backer}, Olivier and David Gall and Schiffmann, {Serge N} and {de Kerchove d'Exaerde}, Alban",
note = "Funding Information: We thank M. Picciotto and M. Mameli for helpful comments and corrections on the manuscript, L. Cuvelier and D. Houtteman for expert technical assistance, S. Guiducci and N. Stasiak for contribution in microdialysis experiments and O. Carret{\'o}n for her contribution in self-administration experiments. We thank F. Tronche (Universit{\'e} Pierre et Marie Currie, Paris, France) for providing DATCre mice; Dr. A. Goffinet and F. Tissir (Universit{\'e} Catholique de Louvain, Brussels, Belgium) for providing Dlx5/6 cre mice and C. L{\"u}scher (University of Geneva, Geneva, Switzerland) and G. Miesenb{\"o}ck (University of Oxford, Oxford, UK) for providing Gad2Cre/WT mice. We are also grateful to F. Lema{\^i}tre, M. Gilles, C. Amatore and J-M. Kauffmann as well as Y. Schmitz, J.E. Lizardi-Ortiz and D. Sulzer for technical advices in fast-scan cyclic voltammetry. JFDB was supported by the Aspirant PhD fellowship from the FRS-FNRS and Van Buuren Funds, BD and AG are supported by the Aspirant PhD fellowship from the FRS-FNRS, JC was supported by a fellowship from the Fonds Erasme and SM was supported by a PhD fellowship from FRIA (Belgium) and a Biowin Program from the Walloon Region. AKE is a Research Director of the FRS-FNRS and an investigator of WELBIO. This study was supported by FMRE-Belgium, FRS-FNRS (Belgium), Interuniversity Attraction Pole (IUAP-P7/10) from Belgian Federal Scientific Affairs and Action de Recherche Concert{\'e}e (FWB). The Foundation for Medical Research (FRM, Equipe FRM 2013 to PF), the Centre National de la Recherche Scientifique CNRS UMR 8246, the University Pierre et Marie Curie UM 119, Institut national de la sant{\'e} et de la recherche m{\'e}dicale INSERM U1130. The Spanish Ministry of Economy (SAF2016-75966R-FEDER), the Generalitat de Catalunya (2014SGR34) and UE Medbioinformatic Project (grant number 634143) to OV. MN was supported by the LabEx Paris-Sciences et Lettres (PSL). The Italian Ministry of Health (RF2009-1549619) to MZ. The Fonds de la Recherche Scientifique-FNRS of the F{\'e}d{\'e}ration Wallonie-Bruxelles to ODB. Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
month = sep,
day = "1",
doi = "10.15252/embr.201745089",
language = "English",
volume = "19",
journal = "EMBO reports",
issn = "1469-221X",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "9",
}
