Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine

Jean-François De Backer, Stéphanie Monlezun, Bérangère Detraux, Adeline Gazan, Laura Vanopdenbosch, Julian Cheron, Giuseppe Cannazza, Sébastien Valverde, Lídia Cantacorps, Mérie Nassar, Laurent Venance, Olga Valverde, Philippe Faure, Michele Zoli, Olivier De Backer, David Gall, Serge N Schiffmann, Alban de Kerchove d'Exaerde

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Résumé

Melanoma antigen genes (Mage) were first described as tumour markers. However, some of Mage are also expressed in healthy cells where their functions remain poorly understood. Here, we describe an unexpected role for one of these genes, Maged1, in the control of behaviours related to drug addiction. Mice lacking Maged1 are insensitive to the behavioural effects of cocaine as assessed by locomotor sensitization, conditioned place preference (CPP) and drug self-administration. Electrophysiological experiments in brain slices and conditional knockout mice demonstrate that Maged1 is critical for cortico-accumbal neurotransmission. Further, expression of Maged1 in the prefrontal cortex (PFC) and the amygdala, but not in dopaminergic or striatal and other GABAergic neurons, is necessary for cocaine-mediated behavioural sensitization, and its expression in the PFC is also required for cocaine-induced extracellular dopamine (DA) release in the nucleus accumbens (NAc). This work identifies Maged1 as a critical molecule involved in cellular processes and behaviours related to addiction.

langue originaleAnglais
Numéro d'articlee45089
journalEMBO J.
Volume19
Numéro de publication9
Date de mise en ligne précoce2018
Les DOIs
étatPublié - 1 sept. 2018
Modification externeOui

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De Backer, J-F., Monlezun, S., Detraux, B., Gazan, A., Vanopdenbosch, L., Cheron, J., ... de Kerchove d'Exaerde, A. (2018). Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine. EMBO J., 19(9), [e45089]. https://doi.org/10.15252/embr.201745089