Deciphering the roles of ABCB5 in normal and cancer cells

Laurent Duvivier; Jean Pierre Gillet

doi:10.1016/j.trecan.2022.07.001

Deciphering the roles of ABCB5 in normal and cancer cells

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Résumé

ABCB5 encodes a full transporter (ABCB5FL) and a half transporter (ABCB5β), which is unique in the ATP binding cassette (ABC) transporter superfamily. We discuss the roles of both isoforms in undifferentiated slow-cycling cells, multidrug resistance, and tumorigenesis, and their regulation pathways.

langue originale	Anglais
Pages (de - à)	795-798
Nombre de pages	4
journal	Trends in Cancer
Volume	8
Numéro de publication	10
Les DOIs	https://doi.org/10.1016/j.trecan.2022.07.001
Etat de la publication	Publié - oct. 2022
Modification externe	Oui

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10.1016/j.trecan.2022.07.001

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title = "Deciphering the roles of ABCB5 in normal and cancer cells",

abstract = "ABCB5 encodes a full transporter (ABCB5FL) and a half transporter (ABCB5β), which is unique in the ATP binding cassette (ABC) transporter superfamily. We discuss the roles of both isoforms in undifferentiated slow-cycling cells, multidrug resistance, and tumorigenesis, and their regulation pathways.",

keywords = "ABCB5, melanocyte biology, melanoma",

author = "Laurent Duvivier and Gillet, {Jean Pierre}",

note = "Funding Information: The authors are grateful to Michael M. Gottesman (Laboratory of Cell Biology, Center for Cancer Research, NCI-NIH, USA) for his critical reading of the manuscript. No interests are declared. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

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AU - Duvivier, Laurent

AU - Gillet, Jean Pierre

N1 - Funding Information: The authors are grateful to Michael M. Gottesman (Laboratory of Cell Biology, Center for Cancer Research, NCI-NIH, USA) for his critical reading of the manuscript. No interests are declared. Publisher Copyright: © 2022 Elsevier Inc.

PY - 2022/10

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AB - ABCB5 encodes a full transporter (ABCB5FL) and a half transporter (ABCB5β), which is unique in the ATP binding cassette (ABC) transporter superfamily. We discuss the roles of both isoforms in undifferentiated slow-cycling cells, multidrug resistance, and tumorigenesis, and their regulation pathways.

KW - ABCB5

KW - melanocyte biology

KW - melanoma

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U2 - 10.1016/j.trecan.2022.07.001

DO - 10.1016/j.trecan.2022.07.001

M3 - Short survey

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SN - 2405-8025

VL - 8

SP - 795

EP - 798

JO - Trends in Cancer

JF - Trends in Cancer

IS - 10

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Deciphering the roles of ABCB5 in normal and cancer cells

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