@article{6b1424db84774ca5b4347206c4f11cfc,
title = "Daily allergy burden and heart rate characteristics in adults with allergic rhinitis based on a wearable telemonitoring system",
abstract = "Background: Allergic rhinitis includes a certain degree of autonomic imbalance. However, no information is available on how daily changes in allergy burden affect autonomic imbalance. We aimed to estimate associations between daily allergy burden (allergy symptoms and mood) and daily heart rate characteristics (resting heart rate and sample entropy, both biomarkers of autonomic balance) of adults with allergic rhinitis, based on real-world measurements with a wearable telemonitoring system. Methods: Adults with a tree pollen allergy used a smartphone application to self-report daily allergy symptoms (score 0–44) and mood (score 0–4), and a Mio Alpha 2 wristwatch to collect heart rate characteristics during two pollen seasons of hazel, alder and birch in Belgium. Associations between daily allergy burden and heart rate characteristics were estimated using linear mixed effects distributed lag models with a random intercept for individuals and adjusted for potential confounders. Results: Analyses included 2497 participant-days of 72 participants. A one-point increase in allergy symptom score was associated with an increase in next-day resting heart rate of 0.08 (95% CI: 0.02–0.15) beats per minute. A one-point increase in mood score was associated with an increase in same-day sample entropy of 0.80 (95% CI: 0.34–1.26) × 10−2. No associations were found between allergy symptoms and heart rate sample entropy, nor between mood and resting heart rate. Conclusion: Daily repeated measurements with a wearable telemonitoring system revealed that the daily allergy burden of adults with allergic rhinitis has systemic effects beyond merely the respiratory system.",
keywords = "allergic rhinitis, heart rate, smartphone, symptoms, telemonitoring",
author = "Joren Buekers and Michiel Stas and Raf Aerts and Nicolas Bruffaerts and Sebastien Dujardin and {Van Nieuwenhuyse}, An and {Van Orshoven}, Jos and Guillaume Chevance and Ben Somers and Aerts, {Jean Marie} and Judith Garcia-Aymerich",
note = "Funding Information: This study is an outcome of the RespirIT project, which has been supported by a grant from the Belgian Science Policy Office BELSPO (grant nr. BR/154/A1/RespirIT). Joren Buekers acknowledges the support of the European Respiratory Society - ERS Long-Term Research Fellowship 2020. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the 'Centro de Excelencia Severo Ochoa 2019-2023′ Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. These organisations only provided financial support and did not play a role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to thank Al{\'i}cia Josa for the support on classifying allergy medication and Xavier Basaga{\~n}a for the support on distributed lag models. Lastly, we would like to thank all participants for their indispensable contributions to the project. Funding Information: This study is an outcome of the RespirIT project, which has been supported by a grant from the Belgian Science Policy Office BELSPO (grant nr. BR/154/A1/RespirIT). Joren Buekers acknowledges the support of the European Respiratory Society ‐ ERS Long‐Term Research Fellowship 2020. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the 'Centro de Excelencia Severo Ochoa 2019‐2023′ Program (CEX2018‐000806‐S), and support from the Generalitat de Catalunya through the CERCA Program. These organisations only provided financial support and did not play a role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to thank Al{\'i}cia Josa for the support on classifying allergy medication and Xavier Basaga{\~n}a for the support on distributed lag models. Lastly, we would like to thank all participants for their indispensable contributions to the project. Publisher Copyright: {\textcopyright} 2023 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.",
year = "2023",
month = apr,
doi = "10.1002/clt2.12242",
language = "English",
volume = "13",
journal = "Clinical and Translational Allergy",
issn = "2045-7022",
publisher = "John Wiley & Sons, Ltd",
number = "4",
}