D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review

Loris Wauthier; Julien Favresse; Michaël Hardy; Jonathan Douxfils; Grégoire Le Gal; Pierre-Marie Roy; Nick van Es; Cihan Ay; Hugo Ten Cate; Thierry Vander Borght; Michaël V Dupont; Thomas Lecompte; Giuseppe Lippi; François Mullier

doi:10.3390/diagnostics12112770

D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review

Loris Wauthier, Julien Favresse, Michaël Hardy, Jonathan Douxfils, Grégoire Le Gal, Pierre-Marie Roy, Nick van Es, Cihan Ay, Hugo Ten Cate, Thierry Vander Borght, Michaël V Dupont, Thomas Lecompte, Giuseppe Lippi, François Mullier

Résultats de recherche: Contribution à un journal/une revue › Article de revue › Revue par des pairs

Résumé

D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.

langue originale	Anglais
Numéro d'article	2770
journal	Diagnostics
Volume	12
Numéro de publication	11
Les DOIs	https://doi.org/10.3390/diagnostics12112770
Etat de la publication	Publié - 12 nov. 2022

Accès au document

10.3390/diagnostics12112770

Autres fichiers et liens

Lien vers la publication sur Scopus

Document sous embargo

12585-2022-Wauthier
369 KB

Clinical Pharmacology Research Group
Douxfils, J., Dogne, J., Musuamba Tshinanu, F., MASEREEL, B., Wieers, G., Haguet, H., RONVAUX, L., Donis, N., Morimont, L., Evrard, J., Siriez, R., Gillot, C., FAVRESSE, J., BOUVY, C., Djokoto, H., Didembourg, M., David, C., Melchionda, S., Maloteau, V., Boucher, A., Devel, P., Modaffari, E., Vandeputte, M., De Messemaeker, A., Decarpentrie, J., Vassart, J. & De Groote, A.
1/04/22 → …
Projet: Axe de recherche

Contient cette citation

@article{280e8dd6affc44c5a299bd0c9cad3446,

title = "D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review",

abstract = "D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.",

keywords = "analytical, D-dimer, In Vitro Diagnostic Regulation, ISO15189, post-analytical, pre-analytical, pulmonary embolism, venous thromboembolism",

author = "Loris Wauthier and Julien Favresse and Micha{\"e}l Hardy and Jonathan Douxfils and {Le Gal}, Gr{\'e}goire and Pierre-Marie Roy and {van Es}, Nick and Cihan Ay and {Ten Cate}, Hugo and {Vander Borght}, Thierry and Dupont, {Micha{\"e}l V} and Thomas Lecompte and Giuseppe Lippi and Fran{\c c}ois Mullier",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = nov,

day = "12",

doi = "10.3390/diagnostics12112770",

language = "English",

volume = "12",

journal = "Diagnostics",

issn = "2075-4418",

publisher = "MDPI AG",

number = "11",

}

TY - JOUR

T1 - D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls

T2 - A Narrative Review

AU - Wauthier, Loris

AU - Favresse, Julien

AU - Hardy, Michaël

AU - Douxfils, Jonathan

AU - Le Gal, Grégoire

AU - Roy, Pierre-Marie

AU - van Es, Nick

AU - Ay, Cihan

AU - Ten Cate, Hugo

AU - Vander Borght, Thierry

AU - Dupont, Michaël V

AU - Lecompte, Thomas

AU - Lippi, Giuseppe

AU - Mullier, François

PY - 2022/11/12

Y1 - 2022/11/12

N2 - D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.

AB - D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.

KW - analytical

KW - D-dimer

KW - In Vitro Diagnostic Regulation

KW - ISO15189

KW - post-analytical

KW - pre-analytical

KW - pulmonary embolism

KW - venous thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=85149447971&partnerID=8YFLogxK

U2 - 10.3390/diagnostics12112770

DO - 10.3390/diagnostics12112770

M3 - Review article

C2 - 36428830

SN - 2075-4418

VL - 12

JO - Diagnostics

JF - Diagnostics

IS - 11

M1 - 2770

ER -

D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review

Résumé

Accès au document

Autres fichiers et liens

Document sous embargo

Empreinte digitale

Projets

Clinical Pharmacology Research Group

Contient cette citation