Cycling hypoxia: A key feature of the tumor microenvironment

Résultats de recherche: Contribution à un journal/une revueArticle de revue

Résumé

A compelling body of evidence indicates that most human solid tumors contain hypoxic areas. Hypoxia is the consequence not only of the chaotic proliferation of cancer cells that places them at distance from the nearest capillary but also of the abnormal structure of the new vasculature network resulting in transient blood flow. Hence two types of hypoxia are observed in tumors: chronic and cycling (intermittent) hypoxia. Most of the current work aims at understanding the role of chronic hypoxia in tumor growth, response to treatment and metastasis. Only recently, cycling hypoxia, with spatial and temporal fluctuations in oxygen levels, has emerged as another key feature of the tumor environment that triggers different responses in comparison to chronic hypoxia. Either type of hypoxia is associated with distinct effects not only in cancer cells but also in stromal cells. In particular, cycling hypoxia has been demonstrated to favor, to a higher extent than chronic hypoxia, angiogenesis, resistance to anti-cancer treatments, intratumoral inflammation and tumor metastasis. These review details these effects as well as the signaling pathway it triggers to switch on specific transcriptomic programs. Understanding the signaling pathways through which cycling hypoxia induces these processes that support the development of an aggressive cancer could convey to the emergence of promising new cancer treatments.

langueAnglais
Pages76-86
Nombre de pages11
journalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1866
Numéro1
Les DOIs
étatPublié - 2016

Empreinte digitale

Tumor Microenvironment
Neoplasms
Neoplasm Metastasis
Hypoxia
Stromal Cells
Cell Proliferation
Oxygen
Inflammation

mots-clés

    Citer ceci

    @article{b23625c1cd0e48f79a0b93d818e9f608,
    title = "Cycling hypoxia: A key feature of the tumor microenvironment",
    abstract = "A compelling body of evidence indicates that most human solid tumors contain hypoxic areas. Hypoxia is the consequence not only of the chaotic proliferation of cancer cells that places them at distance from the nearest capillary but also of the abnormal structure of the new vasculature network resulting in transient blood flow. Hence two types of hypoxia are observed in tumors: chronic and cycling (intermittent) hypoxia. Most of the current work aims at understanding the role of chronic hypoxia in tumor growth, response to treatment and metastasis. Only recently, cycling hypoxia, with spatial and temporal fluctuations in oxygen levels, has emerged as another key feature of the tumor environment that triggers different responses in comparison to chronic hypoxia. Either type of hypoxia is associated with distinct effects not only in cancer cells but also in stromal cells. In particular, cycling hypoxia has been demonstrated to favor, to a higher extent than chronic hypoxia, angiogenesis, resistance to anti-cancer treatments, intratumoral inflammation and tumor metastasis. These review details these effects as well as the signaling pathway it triggers to switch on specific transcriptomic programs. Understanding the signaling pathways through which cycling hypoxia induces these processes that support the development of an aggressive cancer could convey to the emergence of promising new cancer treatments.",
    keywords = "Angiogenesis, Cancer microenvironment, Cycling/intermittent hypoxia, Inflammation, ROS production, Transcriptional response",
    author = "Carine Michiels and C{\'e}line Tellier and Olivier Feron",
    year = "2016",
    doi = "10.1016/j.bbcan.2016.06.004",
    language = "English",
    volume = "1866",
    pages = "76--86",
    journal = "Biochimica et Biophysica Acta - Reviews on Cancer",
    issn = "0304-419X",
    publisher = "Elsevier",
    number = "1",

    }

    Cycling hypoxia : A key feature of the tumor microenvironment. / Michiels, Carine; Tellier, Céline; Feron, Olivier.

    Dans: Biochimica et Biophysica Acta - Reviews on Cancer, Vol 1866, Numéro 1, 2016, p. 76-86.

    Résultats de recherche: Contribution à un journal/une revueArticle de revue

    TY - JOUR

    T1 - Cycling hypoxia

    T2 - Biochimica et Biophysica Acta - Reviews on Cancer

    AU - Michiels,Carine

    AU - Tellier,Céline

    AU - Feron,Olivier

    PY - 2016

    Y1 - 2016

    N2 - A compelling body of evidence indicates that most human solid tumors contain hypoxic areas. Hypoxia is the consequence not only of the chaotic proliferation of cancer cells that places them at distance from the nearest capillary but also of the abnormal structure of the new vasculature network resulting in transient blood flow. Hence two types of hypoxia are observed in tumors: chronic and cycling (intermittent) hypoxia. Most of the current work aims at understanding the role of chronic hypoxia in tumor growth, response to treatment and metastasis. Only recently, cycling hypoxia, with spatial and temporal fluctuations in oxygen levels, has emerged as another key feature of the tumor environment that triggers different responses in comparison to chronic hypoxia. Either type of hypoxia is associated with distinct effects not only in cancer cells but also in stromal cells. In particular, cycling hypoxia has been demonstrated to favor, to a higher extent than chronic hypoxia, angiogenesis, resistance to anti-cancer treatments, intratumoral inflammation and tumor metastasis. These review details these effects as well as the signaling pathway it triggers to switch on specific transcriptomic programs. Understanding the signaling pathways through which cycling hypoxia induces these processes that support the development of an aggressive cancer could convey to the emergence of promising new cancer treatments.

    AB - A compelling body of evidence indicates that most human solid tumors contain hypoxic areas. Hypoxia is the consequence not only of the chaotic proliferation of cancer cells that places them at distance from the nearest capillary but also of the abnormal structure of the new vasculature network resulting in transient blood flow. Hence two types of hypoxia are observed in tumors: chronic and cycling (intermittent) hypoxia. Most of the current work aims at understanding the role of chronic hypoxia in tumor growth, response to treatment and metastasis. Only recently, cycling hypoxia, with spatial and temporal fluctuations in oxygen levels, has emerged as another key feature of the tumor environment that triggers different responses in comparison to chronic hypoxia. Either type of hypoxia is associated with distinct effects not only in cancer cells but also in stromal cells. In particular, cycling hypoxia has been demonstrated to favor, to a higher extent than chronic hypoxia, angiogenesis, resistance to anti-cancer treatments, intratumoral inflammation and tumor metastasis. These review details these effects as well as the signaling pathway it triggers to switch on specific transcriptomic programs. Understanding the signaling pathways through which cycling hypoxia induces these processes that support the development of an aggressive cancer could convey to the emergence of promising new cancer treatments.

    KW - Angiogenesis

    KW - Cancer microenvironment

    KW - Cycling/intermittent hypoxia

    KW - Inflammation

    KW - ROS production

    KW - Transcriptional response

    UR - http://www.scopus.com/inward/record.url?scp=84976465917&partnerID=8YFLogxK

    U2 - 10.1016/j.bbcan.2016.06.004

    DO - 10.1016/j.bbcan.2016.06.004

    M3 - Review article

    VL - 1866

    SP - 76

    EP - 86

    JO - Biochimica et Biophysica Acta - Reviews on Cancer

    JF - Biochimica et Biophysica Acta - Reviews on Cancer

    SN - 0304-419X

    IS - 1

    ER -