Cross-biome comparison of microbial association networks

Karoline Faust, Gipsi Lima-Mendez, Jean Sébastien Lerat, Jarupon F. Sathirapongsasuti, Rob Knight, Curtis Huttenhower, Tom Lenaerts, Jeroen Raes

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Résumé

Clinical and environmental meta-omics studies are accumulating an ever-growing amount of microbial abundance data over a wide range of ecosystems. With a sufficiently large sample number, these microbial communities can be explored by constructing and analyzing co-occurrence networks, which detect taxon associations from abundance data and can give insights into community structure. Here, we investigate how co-occurrence networks differ across biomes and which other factors influence their properties. For this, we inferred microbial association networks from 20 different 16S rDNA sequencing data sets and observed that soil microbial networks harbor proportionally fewer positive associations and are less densely interconnected than host-associated networks. After excluding sample number, sequencing depth and beta-diversity as possible drivers, we found a negative correlation between community evenness and positive edge percentage. This correlation likely results from a skewed distribution of negative interactions, which take place preferentially between less prevalent taxa. Overall, our results suggest an under-appreciated role of evenness in shaping microbial association networks.

langue originaleAnglais
Numéro d'article01200
journalFrontiers in Microbiology
Volume6
Numéro de publicationOCT
Les DOIs
Etat de la publicationPublié - 2015
Modification externeOui

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