Coumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase

Pharmacology, Toxicology and Pharmaceutical Science

• Chymotrypsin 100%
• Ester 100%
• Leukocyte Elastase 100%
• Ester Derivative 100%
• Ligand 50%
• Enzyme 50%
• Histidine 50%
• Coumarin Derivative 50%
• Carbonyl Derivative 50%
• Water 50%
• Methanol 50%
• Glycine 50%
• Thioester 50%
• Ketone Derivative 50%

Chemistry

• Reaction Mechanism 100%
• Ester 100%
• Inhibitor 100%
• Reactivity 66%
• Molecule 33%
• Amino Acid 33%
• Water Type 33%
• Methanol 33%
• Ketone 33%
• Alkylation 33%
• Carbonyl Group 33%
• Coumarin 33%
• Ligand 33%
• % Inhibition 33%
• Nucleophilic Reaction 33%
• Thioester 33%
• Histidine Residue 33%
• Aromatic Ester 33%